Surfing the (endo)cannabinoids wave

Alessandro Finazzi Agrò¹,
Mauro Maccarrone^1,2,*

DOI: 10.1111/febs.12254

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FEBS Journal

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

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This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/febs.12254

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Abstract
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Psychoactive plant extracts have been known for centuries and maybe for thousands of years, and have been used in both folklore and “traditional” medicine. Most of these extracts have also evolved from therapeutic to recreational use, particularly through the enthralling examples of popular gurus and rock stars. Thus, the use of opioids from Papaver species, mescaline from Cactaceae, cocaine from the shrub Erythroxylon coca, psilocybin from mushrooms, and cannabinoids from hemp (Cannabissativa) has spread throughout virtually every country, poor and rich. Meanwhile, researchers and physicians have been trying hard to understand how these plant extracts exert their actions, in the search for active compounds devoid of nasty side effects.

http://onlinelibrary.wiley.com/doi/10.1111/febs.12254/abstract