Eur J Pharmacol. 1994 Jan 15;266(2):193-6.
Glutamatergic regulation of cannabinoid receptor gene expression in the caudate-putamen.
Abstract
Glutamatergic regulation of delta-9-tetrahydrocannabinol (THC) receptor gene expression in the adult rat dorsal striatum following a 2 week unilateral cerebral decortication or pharmacological treatment with MK-801 was investigated by quantitative in situ hybridization. The caudate-putamen on the side of the cerebral decortication contains about 30% significantly lower mRNA levels than the control. In addition, we observed a 52% significant decrease in THC receptor mRNA levels in intact dorsal striatum after treatment with MK-801. Together these results suggest that in vivo, through the NMDA receptor subtype, glutamate up-regulates THC receptor gene expression in the rat caudate-putamen.
- PMID:
- 8157073
- [PubMed – indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
Publication Types
MeSH Terms
- Animals
- Cerebral Decortication
- Corpus Striatum/drug effects
- Corpus Striatum/physiology*
- Dizocilpine Maleate/pharmacology*
- Gene Expression Regulation
- In Situ Hybridization
- Male
- RNA, Messenger/analysis
- Rats
- Rats, Wistar
- Receptors, Cannabinoid
- Receptors, Drug/drug effects
- Receptors, Drug/genetics*
Substances
