Tag Archives: Antinociception
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Cannabinoids-induced peripheral analgesia depends on activation of BK channels.

Brain Res. 2019 Jan 4. pii: S0006-8993(19)30007-1. doi: 10.1016/j.brainres.2019.01.007. [Epub ahead of print] Li Y1, Zhang L1, Wu Y1, Zheng Q1, Chen M2, Qian Z1, Wei C1, Han J1, Liu Z1, Ren W1, Lui Y1. Author information Abstract The endogenous cannabinoid system is involved in the physiological inhibitory control of pain and is of particular […]

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Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice.

Brain Res Bull. 2018 Feb 6. pii: S0361-9230(17)30762-1. doi: 10.1016/j.brainresbull.2018.02.003. [Epub ahead of print] Wang P1, Zheng T1, Zhang M1, Xu B1, Zhang R1, Zhang T1, Zhao W1, Shi X1, Zhang Q1, Fang Q2. Author information Abstract Cannabinoids (CBs) play important roles in pain modulation. Recently, VD-hemopressin(β) [VD-Hpβ], a 12-residue β-hemoglobin-derived peptide, was reported to […]

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CB1 cannabinoid receptor agonist mouse VD-hemopressin(α) produced supraspinal analgesic activity in the preclinical models of pain.

Brain Res. 2017 Dec 21. pii: S0006-8993(17)30547-4. doi: 10.1016/j.brainres.2017.12.013. [Epub ahead of print] Zheng T1, Zhang R1, Zhang T2, Zhang MN2, Xu B2, Song JJ2, Li N2, Tang HH2, Wang P2, Wang R3, Fang Q4. Author information Abstract Mouse VD-hemopressin(α) (VD-Hpα) is an undecapeptide that selectively activates CB1 cannabinoid receptor in in vitro functional tests, […]

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The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice.

Int J Mol Sci. 2017 Oct 28;18(11). pii: E2268. doi: 10.3390/ijms18112268. McDonnell C1,2, Leánez S3,4, Pol O5,6. Author information Abstract The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 […]

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Anti-migraine effect of ∆9-tetrahydrocannabinol in the female rat.

Eur J Pharmacol. 2017 Oct 27. pii: S0014-2999(17)30723-9. doi: 10.1016/j.ejphar.2017.10.054. [Epub ahead of print] Kandasamy R1, Dawson CT2, Craft RM3, Morgan MM4. Author information Abstract Current anti-migraine treatments have limited efficacy and many side effects. Although anecdotal evidence suggests that marijuana is useful for migraine, this hypothesis has not been tested in a controlled experiment. […]

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Antinociceptive effects of JWH015 in female and male rats.

Behav Pharmacol. 2017 Sep 13. doi: 10.1097/FBP.0000000000000337. [Epub ahead of print] Craft RM1, Greene NZ, Wakley AA. Author information Abstract Despite greater chronic pain prevalence in females compared with males, and the analgesic potential of cannabinoid receptor type 2 (CB2) agonists, CB2 agonists have rarely been tested in females. The aim of the present study […]


Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists.

Neuropharmacology. 2016 Dec 19. pii: S0028-3908(16)30563-9. doi: 10.1016/j.neuropharm.2016.12.008. [Epub ahead of print] Grenald SA1, Young MA1, Wang Y1, Ossipov MH1, Ibrahim MM1, Largent-Milnes TM1, Vanderah TW2. Author information Abstract The misuse of prescription opiates is on the rise with combination therapies (e.g. acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years, cannabinoid receptors have been identified as potential modulators of […]


Pharmacological characterization of rat VD-hemopressin(α), an α-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice.

Neuropeptides. 2016 Dec 16. pii: S0143-4179(16)30171-8. doi: 10.1016/j.npep.2016.12.006. [Epub ahead of print] Zheng T1, Zhang T1, Zhang R1, Wang ZL1, Han ZL1, Li N1, Li XH1, Zhang MN1, Xu B1, Yang XL1, Fang Q2, Wang R3. Author information Abstract Hemopressin and related peptides have shown to function as the endogenous ligands or the regulator of cannabinoid receptors. Moreover, hemopressin and its truncated peptides were also reported to […]


β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.

2016 Sep 30. doi: 10.1002/cam4.816. [Epub ahead of print] Fidyt K1,2, Fiedorowicz A1, Strządała L1, Szumny A2. Author information Abstract Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic […]

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The Effect of Muscarinic Receptor Modulators on the Antinociception Induced by CB2 Receptor Agonist, JWH133 in Mice.

 2016 Aug 9. [Epub ahead of print] Alipour M1, Fekrmandi F2, Onsori S1, Tabrizian P1, Jafari MR1. Author information Abstract There is no published study regarding the interaction between muscarinic receptor modulators and antinociception induced by cannabinoidreceptor (CB2) agonist. The effect of pilocarpine (a muscarinic agonist) and atropine (a muscarinic antagonist) on JWH-133 (a CB2 agonist) induced analgesia in mice was […]