Tag Archives: cancer
PM 2 site 207

Medical Marijuana Use in a Community Cancer Center.

J Oncol Pract. 2018 Sep;14(9):e566-e578. doi: 10.1200/JOP.18.00057. Saadeh CE1, Rustem DR1. Author information Abstract PURPOSE: The primary purpose of this study was to compare the incidence of marijuana use between patients with early- versus advanced-stage cancers. Differences in adverse effects, drug-drug interactions, and drug-disease interactions between those who use marijuana and those who do not […]

PM 2 site 207

Cannabinoids in cancer treatment: Therapeutic potential and legislation.

Bosn J Basic Med Sci. 2018 Sep 2. doi: 10.17305/bjbms.2018.3532. [Epub ahead of print] Dariš B1, Tancer Verboten M, Knez Ž, Ferk P. Author information Abstract The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, […]

PM 2 site 207

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer.

Front Pharmacol. 2018 Aug 13;9:889. doi: 10.3389/fphar.2018.00889. eCollection 2018. Kosgodage US1, Mould R2, Henley AB2, Nunn AV2, Guy GW3, Thomas EL2, Inal JM4, Bell JD2, Lange S5,6. Author information Abstract Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release […]

PM 2 site 207

Cannabinoid pharmacology and therapy in gut disorders.

Biochem Pharmacol. 2018 Aug 1. pii: S0006-2952(18)30318-6. doi: 10.1016/j.bcp.2018.07.048. [Epub ahead of print] Uranga JA1, Vera G2, Abalo R3. Author information Abstract Cannabis sp and their products (marijuana, hashish…), in addition to their recreational, industrial and other uses, have a long history for their use as a remedy for symptoms related with gastrointestinal diseases. After […]

PM 2 site 207

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.

Oncogene. 2018 Jul 30. doi: 10.1038/s41388-018-0390-1. [Epub ahead of print] Ferro R1, Adamska A2, Lattanzio R3, Mavrommati I1, Edling CE1, Arifin SA1, Fyffe CA1, Sala G3, Sacchetto L4, Chiorino G4, De Laurenzi V2,3, Piantelli M3, Sansom OJ5, Maffucci T1, Falasca M6,7. Author information Abstract The life expectancy for pancreatic cancer patients has seen no substantial […]

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Emerging strategies targeting cb2 cannabinoid receptor: biased agonism and allosterism.

Biochem Pharmacol. 2018 Jul 25. pii: S0006-2952(18)30299-5. doi: 10.1016/j.bcp.2018.07.031. [Epub ahead of print] Morales P1, Goya P1, Jagerovic N2. Author information Abstract During these last years, the CB2 cannabinoid receptor has emerged as a potential anti-inflammatory target in diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, ischemic stroke, autoimmune diseases, osteoporosis, and cancer. […]

PM 2 site 207

Therapeutic applications of cannabinoids.

Chem Biol Interact. 2018 Jul 21. pii: S0009-2797(18)30737-3. doi: 10.1016/j.cbi.2018.07.018. [Epub ahead of print] Velmurugan BK1. Author information Abstract The psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are […]

PM 2 site 207

Anti-tumoural actions of cannabinoids.

Br J Pharmacol. 2018 Jul 17. doi: 10.1111/bph.14426. [Epub ahead of print] Hinz B1, Ramer R1. Author information Abstract The endocannabinoid system has emerged as a considerable target for the treatment of diverse diseases. In addition to the well-established palliative effects of cannabinoids in cancer therapy, phytocannabinoids, synthetic cannabinoid compounds as well as inhibitors of […]

PM 2 site 207

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells.

Int J Mol Sci. 2018 Jul 4;19(7). pii: E1958. doi: 10.3390/ijms19071958. Capozzi A1, Mattei V2, Martellucci S3,4, Manganelli V5, Saccomanni G6, Garofalo T7, Sorice M8, Manera C9, Misasi R10. Author information Abstract Several studies demonstrated that cannabinoids reduce tumor growth, inhibit angiogenesis, and decrease cancer cell migration. As these molecules are well tolerated, it would […]

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Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.

Nat Commun. 2018 Jul 3;9(1):2574. doi: 10.1038/s41467-018-04999-8. Xiang W1, Shi R1, Kang X1, Zhang X2, Chen P3, Zhang L1, Hou A1, Wang R1, Zhao Y1, Zhao K1, Liu Y1, Ma Y1, Luo H1, Shang S1, Zhang J4, He F1, Yu S2, Gan L1, Shi C5, Li Y6, Yang W7, Liang H8, Miao H9. Author information […]