Tag Archives: Cannabidiol

Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats.

Psychopharmacology (Berl). 2018 Jun 16. doi: 10.1007/s00213-018-4946-0. [Epub ahead of print] Javadi-Paydar M1, Nguyen JD1, Kerr TM1, Grant Y1, Vandewater SA1, Cole M2, Taffe MA3. Author information Abstract RATIONALE: Previous studies report sex differences in some, but not all, responses to cannabinoids in rats. The majority of studies use parenteral injection; however, most human use […]

The impact of Cannabidiol treatment on regulatory T-17 Cells and neutrophil polarization in Acute Kidney Injury.

Am J Physiol Renal Physiol. 2018 Jun 13. doi: 10.1152/ajprenal.00112.2018. [Epub ahead of print] Baban B1, Hoda MN2, Malik A3, Khodadadi H3, Simmerman E, Vaibhav K4, Mozaffari MS3. Author information Abstract Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils […]

Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity.

Eur Neuropsychopharmacol. 2018 Jun 7. pii: S0924-977X(18)30113-5. doi: 10.1016/j.euroneuro.2018.04.004. [Epub ahead of print] Grimm O1, Löffler M2, Kamping S3, Hartmann A2, Rohleder C4, Leweke M4, Flor H2. Author information Abstract Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are two substances from cannabis sativa that have been implicated in the treatment of mental and neurological disorders. We concentrated […]

Cannabidiol did not induce teratogenicity or neurotoxicity in exposed zebrafish embryos.

Chem Biol Interact. 2018 Jun 11. pii: S0009-2797(18)30216-3. doi: 10.1016/j.cbi.2018.06.008. [Epub ahead of print] Valim Brigante TA1, Abe FR2, Zuardi AW3, Hallak JEC3, Crippa JAS3, de Oliveira DP4. Author information Abstract Cannabidiol (CBD) is a non-psychotomimetic compound of the Cannabis sativa that has been used for the treatment of severe epilepsy as well as other […]

The importance of 15-lipoxygenase inhibitors in cancer treatment.

Cancer Metastasis Rev. 2018 Jun 7. doi: 10.1007/s10555-018-9738-9. [Epub ahead of print] Orafaie A1, Matin MM1,2, Sadeghian H3,4. Author information Abstract Cancer-targeted therapy is an expanding and successful approach in treatment of many types of cancers. One of the main categories of targeted therapy is use of small molecule inhibitors. 15-Lipoxygenase (15-LOX) is an enzyme […]

Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 6. pii: S0278-5846(18)30116-7. doi: 10.1016/j.pnpbp.2018.06.002. [Epub ahead of print] Sales AJ1, Crestani CC2, Guimarães FS3, Joca SRL4. Author information Abstract Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in several neuropsychiatric disorders including depression. CBD treatment has shown significant antidepressant-like effects in different rodent preclinical […]

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex.

Mol Neurobiol. 2018 Jun 4. doi: 10.1007/s12035-018-1143-4. [Epub ahead of print] Sales AJ1,2, Fogaça MV1,2, Sartim AG1,2, Pereira VS3, Wegener G3, Guimarães FS1,4, Joca SRL5,6,7. Author information Abstract Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical […]

Effects of cannabidiol plus naltrexone on motivation and ethanol consumption.

Br J Pharmacol. 2018 Jun 2. doi: 10.1111/bph.14380. [Epub ahead of print] Viudez-Martínez A1, García-Gutiérrez MS1,2, Fraguas-Sánchez AI3, Torres-Suárez AI3, Manzanares J1,2. Author information Abstract BACKGROUND AND PURPOSE: The aim of this study was to explore if the administration of naltrexone (NTX) together with cannabidiol (CBD) may improve the efficacy in reducing alcohol consumption and […]

Investigational cannabinoids in seizure disorders, what have we learned thus far?

Expert Opin Investig Drugs. 2018 May 29. doi: 10.1080/13543784.2018.1482275. [Epub ahead of print] Ružić Zečević D1, Folić M1, Tantoush Z1, Radovanović M1, Babić G1, Janković SM1. Author information Abstract The anticonvulsant activity of cannabinoids attracted much attention in the last decade. Cannabinoids that are currently investigated with the intention of making them drugs for the […]

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort.

J Headache Pain. 2018 May 24;19(1):37. doi: 10.1186/s10194-018-0862-2. Baron EP1, Lucas P2,3,4, Eades J2, Hogue O5. Author information Abstract BACKGROUND: Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthritis and chronic pain, […]