Tag Archives: cardiovascular disorders

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.

JCI Insight. 2017 Jun 15;2(12). pii: 93760. doi: 10.1172/jci.insight.93760. [Epub ahead of print] Jadoon KA1, Tan GD2, O’Sullivan SE1. Author information Abstract BACKGROUND: Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. The aim […]

The endocannabinoid system: no longer anonymous in the control of nitrergic signalling?

J Mol Cell Biol. 2017 Jan 27. pii: mjx008. doi: 10.1093/jmcb/mjx008. [Epub ahead of print] Lipina C1, Hundal HS2. Author information Abstract The endocannabinoid system (ECS) is a key cellular signalling system that has been implicated in the regulation of diverse cellular functions. Importantly, growing evidence suggests that the biological actions of the ECS may, in part, […]

ENDOCANNABINOID SYSTEM: A multi-facet therapeutic target.

2016 Apr 17. [Epub ahead of print] Kaur R1, Ambwani SR, Singh S. Author information Abstract Cannabis sativa is also popularly known as marijuana. It is being cultivated and used by man for recreational and medicinal purposes from many centuries. Study of cannabinoids was at bay for very long time and its therapeutic value could not be adequately harnessed […]

Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists

Review Mojgan Aghazadeh Tabrizi†, Pier Giovanni Baraldi*†, Pier Andrea Borea‡, and Katia Varani‡ †Department of Chemical and Pharmaceutical Sciences and ‡Department of Medical Science, Pharmacology Section, University of Ferrara, Ferrara 44121, Italy Chem. Rev., 2016, 116 (2), pp 519–560 DOI: 10.1021/acs.chemrev.5b00411 Publication Date (Web): January 07, 2016 Copyright © 2016 American Chemical Society *Phone: 0039-0532- 455921. Fax: 0039-0532- 455953. E-mail: baraldi@unife.it. Biography Mojgan Aghazadeh Tabrizi received her B.S. […]