Tag Archives: epilepsy

Open-label use of Highly* purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes.

Epilepsy Behav. 2018 Jul 10. pii: S1525-5050(18)30191-4. doi: 10.1016/j.yebeh.2018.05.013. [Epub ahead of print] Devinsky O1, Verducci C2, Thiele EA3, Laux LC4, Patel AD5, Filloux F6, Szaflarski JP7, Wilfong A8, Clark GD9, Park YD10, Seltzer LE11, Bebin EM12, Flamini R13, Wechsler RT14, Friedman D15. Author information Abstract OBJECTIVE: We studied our collective open-label, compassionate use experience […]

Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community.

Sci Rep. 2018 Jul 5;8(1):10154. doi: 10.1038/s41598-018-28127-0. Suraev A1, Lintzeris N2,3, Stuart J1, Kevin RC1, Blackburn R1, Richards E1, Arnold JC1,4, Ireland C5, Todd L5, Allsop DJ1, McGregor IS6. Author information Abstract Recent surveys suggest that many parents are using illicit cannabis extracts in the hope of managing seizures in their children with epilepsy. In […]

Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases.

Molecules. 2018 Jun 25;23(7). pii: E1526. doi: 10.3390/molecules23071526. Prandi C1, Blangetti M2, Namdar D3, Koltai H4. Author information Abstract Cannabis sativa active compounds are extensively studied for their therapeutic effects, beyond the well-known psychotropic activity. C. Sativa is used to treat different medical indications, such as multiple sclerosis, spasticity, epilepsy, ulcerative colitis and pain. Simultaneously, […]

Cannabis, cannabis everywhere: UK to review medical cannabis policy as Canada plans imminent legalisation for all uses

Feature War on Drugs BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k2695 (Published 19 June 2018)Cite this as: BMJ 2018;361:k2695 Editorial Cannabis as medicine Opinion Medical cannabis: it is time to provide legal access, the UK must not get left behind Article Related c Richard Hurley, features editor, The BMJ rhurley@bmj.com As the UK government weathers sustained criticism […]

The adult motor phenotype of Dravet syndrome is associated with mutation of the STXBP1 gene and responds well to cannabidiol treatment.

Seizure. 2018 Jun 13;60:68-70. doi: 10.1016/j.seizure.2018.06.010. [Epub ahead of print] Álvarez Bravo G1, Yusta Izquierdo A2. Author information Abstract Dravet syndrome is a terrible disease generally caused by mutations of the SCN1A gene. Recently others genes such as STXBP1 have been involved in the pathogenesis of the disease. The STXBP1 mutation in patients with Dravet […]

Therapeutic potential of medicinal marijuana: an educational primer for health care professionals.

Drug Healthc Patient Saf. 2018 Jun 11;10:45-66. doi: 10.2147/DHPS.S158592. eCollection 2018. Mouhamed Y#1, Vishnyakov A#1, Qorri B#2, Sambi M#2, Frank SS1, Nowierski C1, Lamba A1, Bhatti U1, Szewczuk MR2. Author information Abstract With the proposed Canadian July 2018 legalization of marijuana through the Cannabis Act, a thorough critical analysis of the current trials on the […]

Faces of Cannabis, Manitoba; Brittany Maydaniuk

Meet sports fan, enthusiast of videography, photography, music and toons ;),  also an activist/advocate born & raised in Winnipeg, and one of Manitoba’s faces of Cannabis, Brittany Maydaniuk. Brittany has smoked cannabis recreationally for years but started using cannabis as medicine in 2014. Brittany was diagnosed with Photosensitive Epilepsy at the age 15 after having […]

Investigational cannabinoids in seizure disorders, what have we learned thus far?

Expert Opin Investig Drugs. 2018 May 29. doi: 10.1080/13543784.2018.1482275. [Epub ahead of print] Ružić Zečević D1, Folić M1, Tantoush Z1, Radovanović M1, Babić G1, Janković SM1. Author information Abstract The anticonvulsant activity of cannabinoids attracted much attention in the last decade. Cannabinoids that are currently investigated with the intention of making them drugs for the […]

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome.

N Engl J Med. 2018 May 17;378(20):1888-1897. doi: 10.1056/NEJMoa1714631. Devinsky O1, Patel AD1, Cross JH1, Villanueva V1, Wirrell EC1, Privitera M1, Greenwood SM1, Roberts C1, Checketts D1, VanLandingham KE1, Zuberi SM1; GWPCARE3 Study Group. Author information Abstract Background Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy […]

Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling.

Cell Mol Life Sci. 2018 May 8. doi: 10.1007/s00018-018-2834-8. [Epub ahead of print] Sugaya Y1,2, Kano M3,4. Author information Abstract Progress in research on endocannabinoid signaling has greatly advanced our understanding of how it controls neural circuit excitability in health and disease. In general, endocannabinoid signaling at excitatory synapses suppresses seizures by inhibiting glutamate release. […]