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Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress.

J Psychopharmacol. 2018 Oct 16:269881118805495. doi: 10.1177/0269881118805495. [Epub ahead of print] Viudez-Martínez A1, García-Gutiérrez MS1,2, Manzanares J1,2. Author information Abstract BACKGROUND: Research interest has grown around the potential therapeutic use of cannabidiol in mood-related disorders, due to its anxiolytic and antidepressant-like effects. These have been partially attributed to its action as an allosteric modulator of […]

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Adolescent arrestees detained in police cells: an observational study in the Paris, France, area.

Int J Legal Med. 2018 Oct 15. doi: 10.1007/s00414-018-1942-1. [Epub ahead of print] Coudert C1, Vidal C1, Lefèvre T1,2, Chariot P3,4. Author information Abstract OBJECTIVE: Custody conditions in police cells are often demeaning and considered inappropriate for human beings. The detention of young adolescents in police custody has received little attention. Our study aimed to […]

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Watching Canada’s experiment with legal cannabis

Editorial Diane Kelsall CMAJ October 15, 2018 190 (41) E1218; DOI: https://doi.org/10.1503/cmaj.181287 Article Responses Metrics PDF On Oct. 17, 2018, the government of Canada will launch a national, uncontrolled experiment in which the profits of cannabis producers and tax revenues are squarely pitched against the health of Canadians. When Bill C-45 comes into force in […]

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New Methods for the Comprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp).

Molecules. 2018 Oct 14;23(10). pii: E2639. doi: 10.3390/molecules23102639. Pellati F1, Brighenti V2, Sperlea J3,4, Marchetti L5, Bertelli D6, Benvenuti S7. Author information Abstract Cannabis sativa L. is a dioecious plant belonging to the Cannabaceae family. The main phytochemicals that are found in this plant are represented by cannabinoids, flavones, and terpenes. Some biological activities of […]

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Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists.

Molecules. 2018 Oct 13;23(10). pii: E2630. doi: 10.3390/molecules23102630. Pandey P1, Roy KK2,3, Liu H4, Ma G5, Pettaway S6, Alsharif WF7, Gadepalli RS8, Rimoldi JM9,10, McCurdy CR11,12, Cutler SJ13,14, Doerksen RJ15,16. Author information Abstract Natural products are an abundant source of potential drugs, and their diversity makes them a rich and viable prospective source of bioactive […]

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Cannabis use and non-cancer chronic pain

CORRESPONDENCE| VOLUME 3, ISSUE 10, PE468, OCTOBER 01, 2018 Cannabis use and non-cancer chronic pain Download PDF [32 KB] Save Share Reprints Request Top Alex Bekker Open AccessPublished:October, 2018DOI:https://doi.org/10.1016/S2468-2667(18)30178-6 PlumX Metrics References Article Info Linked Article I read with interest the Article by Gabrielle Campbell and colleagues.1 The authors should be commended on completion of this […]

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Cannabidiol affects circadian clock core complex and its regulation in microglia cells.

Addict Biol. 2018 Oct 11. doi: 10.1111/adb.12660. [Epub ahead of print] Lafaye G1,2, Desterke C3, Marulaz L1,2, Benyamina A1,2. Author information Abstract Cannabis is often used by consumers for sleep disorders. Studies show that circadian rhythm could be affected by a misuse of cannabis. Recent research has connected the role of microglial cells with psychiatric […]

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Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus.

Cereb Cortex. 2018 Oct 11. doi: 10.1093/cercor/bhy258. [Epub ahead of print] Zimmermann T1, Maroso M2, Beer A1, Baddenhausen S1, Ludewig S3, Fan W1, Vennin C1,4, Loch S1, Berninger B1,5, Hofmann C1, Korte M3,6, Soltesz I2, Lutz B1,4, Leschik J1. Author information Abstract Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific […]

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A novel GABAergic dysfunction in human Dravet syndrome.

Epilepsia. 2018 Oct 11. doi: 10.1111/epi.14574. [Epub ahead of print] Ruffolo G1, Cifelli P1,2, Roseti C3, Thom M4, van Vliet EA5,6, Limatola C1,2, Aronica E5,7, Palma E1,3. Author information Abstract OBJECTIVE: Dravet syndrome is a rare neurodevelopmental disease, characterized by general cognitive impairment and severe refractory seizures. The majority of patients carry the gene mutation […]

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The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus.

Epilepsy Res. 2018 Oct 9;148:8-16. doi: 10.1016/j.eplepsyres.2018.10.002. [Epub ahead of print] Wu Q1, Wang H2. Author information Abstract OBJECTIVE: To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-induced status epilepticus rats hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE). METHODS: A total of 112 male Sprague-Dawley rats […]