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Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.

Neuropathol Appl Neurobiol. 2018 Apr 21. doi: 10.1111/nan.12492. [Epub ahead of print] Panja D1, Vedeler CA1,2, Schubert M2. Author information Abstract AIM: Neurodegeneration is associated with dysfunction of calcium buffering capacity and thereby sustained cellular and mitochondrial calcium overload. Paraneoplastic cerebellar degeneration (PCD), characterized by progressive Purkinje neuron degeneration following paraneoplastic Yo antibody internalisation and […]

A Twitter-based survey on marijuana concentrate use.

Drug Alcohol Depend. 2018 Apr 11;187:155-159. doi: 10.1016/j.drugalcdep.2018.02.033. [Epub ahead of print] Daniulaityte R1, Zatreh MY2, Lamy FR3, Nahhas RW4, Martins SS5, Sheth A6, Carlson RG7. Author information Abstract AIMS: The purpose of this paper is to analyze characteristics of marijuana concentrate users, describe patterns and reasons of use, and identify factors associated with daily […]

Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons.

Mol Pharmacol. 2018 Apr 18. pii: mol.118.111864. doi: 10.1124/mol.118.111864. [Epub ahead of print] Straiker A1, Dvorakova M2, Zimmowitch A2, Mackie KP2. Author information Abstract Δ9-THC and cannabidiol (CBD) are two main cannabinoid constituents of marijuana and hashish. The pharmacology of Δ9-THC has been extensively studied, while our understanding of the pharmacology of CBD has remained […]

Cannabinoid Receptor Type 1 Expression in the Developing Avian Retina: Morphological and Functional Correlation With the Dopaminergic System.

Front Cell Neurosci. 2018 Mar 12;12:58. doi: 10.3389/fncel.2018.00058. eCollection 2018. da Silva Sampaio L1, Kubrusly RCC2, Colli YP1, Trindade PP1, Ribeiro-Resende VT1, Einicker-Lamas M3, Paes-de-Carvalho R4, Gardino PF1, de Mello FG1, De Melo Reis RA1. Author information Abstract The avian retina has been used as a model to study signaling by different neuro- and gliotransmitters. […]

Medical Marijuana Use in Older Adults.

J Am Geriatr Soc. 2018 Apr 18. doi: 10.1111/jgs.15346. [Epub ahead of print] Briscoe J1, Casarett D1. Author information Abstract Symptom management in older adults, including pain and distressing non-pain symptoms, can be challenging. Medications can cause side effects that worsen quality of life or create other symptoms, and polypharmacy itself can be detrimental in […]

Medical Marijuana Users are More Likely to Use Prescription Drugs Medically and Nonmedically.

J Addict Med. 2018 Apr 17. doi: 10.1097/ADM.0000000000000405. [Epub ahead of print] Caputi TL1, Humphreys K. Author information Abstract OBJECTIVES: Previous studies have found a negative population-level correlation between medical marijuanaavailability in US states, and trends in medical and nonmedical prescription drug use. These studies have been interpreted as evidence that use of medical marijuana […]

Does Medical Cannabis Use Increase or Decrease the Use of Opioid Analgesics and Other Prescription Drugs?

J Addict Med. 2018 Apr 17. doi: 10.1097/ADM.0000000000000404. [Epub ahead of print] Bachhuber MA1, Arnsten JH, Cunningham CO, Sohler N. Author information Abstract : In observational and retrospective studies, people who use cannabis are more likely than people who do not use cannabis to also use other drugs. People who take medical cannabis are also […]

Dentification and quantification of quercetin, a major consitituent of artocarpus altilis by targeting related genes of apoptosis and cell cycle: in vitro cytotoxic activity against human lung carcinoma cell lines (A549).

Curr Med Chem. 2018 Apr 17. doi: 10.2174/0929867325666180417165247. [Epub ahead of print] Russo S1, De Azevedo WF1. Author information Abstract BACKGROUND: Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in the central nervous system, whose crystallographic structure has recently been solved. Studies will be needed to investigate CB1 complexes with its ligands and its […]

Positron emission tomography imaging of cerebral glucose metabolism and type 1 cannabinoid receptor availability during temporal lobe epileptogenesis in the amygdala kindling model in rhesus monkeys.

Epilepsia. 2018 Apr 17. doi: 10.1111/epi.14059. [Epub ahead of print] Cleeren E1,2, Casteels C3,4, Goffin K3,4, Koole M3,4, Van Laere K3,4, Janssen P1, Van Paesschen W2. Author information Abstract OBJECTIVE: We investigated changes in the endocannabinoid system and glucose metabolism during temporal lobe epileptogenesis. METHODS: Because it is rarely possible to study epileptogenesis in humans, […]

Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents – An observational, longitudinal study.

Brain Dev. 2018 Apr 16. pii: S0387-7604(18)30112-8. doi: 10.1016/j.braindev.2018.03.013. [Epub ahead of print] Hausman-Kedem M1, Menascu S2, Kramer U2. Author information Abstract The objective of this observational study was to evaluate the efficacy of medical cannabis for the treatment of refractory epilepsy. Fifty-seven patients (age 1-20 years) with epilepsy of various etiologies were treated with Cannabis […]