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A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety.

Curr Oncol Rep. 2019 Feb 1;21(1):10. doi: 10.1007/s11912-019-0757-7. Steele G1, Arneson T2, Zylla D3,4. Author information Abstract PURPOSE OF REVIEW: As the legalization of medical cannabis continues across the USA, oncology care providers will be increasingly asked to provide recommendations regarding its use in the cancer setting. In this article, we review recent literature that […]

PM 2 site 207

Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner.

Cancers (Basel). 2019 Jan 31;11(2). pii: E161. doi: 10.3390/cancers11020161. Hohmann T1, Feese K2, Greither T3, Ghadban C4, Jäger V5, Dehghani F6, Grabiec U7. Author information Abstract The current treatment of glioblastoma is not sufficient, since they are heterogeneous and often resistant to chemotherapy. Earlier studies demonstrated effects of specific cannabinoid receptor (CB) agonists on the […]

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Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?

Eur Arch Psychiatry Clin Neurosci. 2019 Jan 31. doi: 10.1007/s00406-019-00982-6. [Epub ahead of print] Crippa JAS1,2,3, Hallak JEC4,5, Zuardi AW4,5, Guimarães FS5,6, Tumas V4,5, Dos Santos RG4,5. Author information Abstract Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized […]

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Cannabinoids and Bone Regeneration.

Drug Metab Rev. 2019 Jan 31:1-20. doi: 10.1080/03602532.2019.1574303. [Epub ahead of print] Apostu D1, Lucaciu O2, Mester A2, Benea H1, Oltean-Dan D1, Onisor F3, Baciut M3, Bran S3. Author information Abstract Bone is a complex tissue of the with unique properties such as high strength and regeneration capabilities while carrying out multiple functions. Bone regeneration […]

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Diet-Induced Obesity in Cannabinoid-2 Receptor Knockout Mice and Cannabinoid Receptor 1/2 Double-Knockout Mice.

Obesity (Silver Spring). 2019 Jan 30. doi: 10.1002/oby.22403. [Epub ahead of print] Alshaarawy O1, Kurjan E2, Truong N2, Olson LK2. Author information Abstract OBJECTIVE: Evidence suggests that cannabinoid-1 receptor (CB1R) activation is associated with increased food intake and body weight gain. Human epidemiological studies, however, show decreased prevalence of obesity in cannabis users. Given the […]

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Cannabidiol as a novel candidate alcohol use disorder pharmacotherapy: a systematic review.

Alcohol Clin Exp Res. 2019 Jan 30. doi: 10.1111/acer.13964. [Epub ahead of print] Turna J1,2, Syan SK2,3,4, Frey BN4,5, Rush B6, Costello J6, Weiss M7, MacKillop J1,2,3,4,6. Author information Abstract There is substantial interest in the therapeutic potential of cannabidiol (CBD), a non-psychoactive cannabinoid found in plants of the genus Cannabis. The goal of the current […]

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Decarbonylation: a metabolic pathway of cannabidiol in humans.

Drug Test Anal. 2019 Jan 30. doi: 10.1002/dta.2572. [Epub ahead of print] Kraemer M1, Broecker S2, Madea B1, Hess C1,3. Author information Abstract Cannabidiol (CBD) is a non-psychoactive cannabinoid, which is of growing medical interest. Previous studies on the metabolism of CBD showed mainly the formation of hydroxylated or oxidized derivatives, of carboxylic acids or […]

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The annual cannabis holiday and fatal traffic crashes.

Inj Prev. 2019 Jan 29. pii: injuryprev-2018-043068. doi: 10.1136/injuryprev-2018-043068. [Epub ahead of print] Harper S1, Palayew A2. Author information Abstract BACKGROUND: Cannabis use has been linked to impaired driving and fatal accidents. Prior evidence suggests the potential for population-wide effects of the annual cannabis celebration on April 20th (‘4/20’), but evidence to date is limited. […]

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Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities.

Front Pharmacol. 2019 Jan 9;9:1521. doi: 10.3389/fphar.2018.01521. eCollection 2018. Barchel D1, Stolar O2, De-Haan T1, Ziv-Baran T3, Saban N4, Fuchs DO1, Koren G1,5, Berkovitch M1. Author information Abstract Objective: Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Several studies are being conducted worldwide on cannabidiol use in […]