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PM 2 site 207

Cannabis shenanigans: advocating for the restoration of an effective treatment of pain following spinal cord injury.

Spinal Cord Ser Cases. 2018 Aug 7;4:67. doi: 10.1038/s41394-018-0096-1. eCollection 2018. Graves DE1. Author information Abstract Cannabis is an effective treatment for pain following spinal cord injury that should be available to patients and researchers. The major argument against the rescheduling of cannabis is that the published research is not convincing. This argument is disingenuous […]

PM 2 site 207

Current natural therapies in the treatment against glioblastoma.

Phytother Res. 2018 Aug 15. doi: 10.1002/ptr.6170. [Epub ahead of print] Erices JI1, Torres Á1, Niechi I1, Bernales I1, Quezada C2. Author information Abstract Glioblastoma (GBM) is the most common and aggressive brain tumor, which causes the highest number of deaths worldwide. It is a highly vascularized tumor, infiltrative, and its tumorigenic capacity is exacerbated. […]

PM 2 site 207

New approaches and challenges to targeting the endocannabinoid system.

Nat Rev Drug Discov. 2018 Aug 17. doi: 10.1038/nrd.2018.115. [Epub ahead of print] Di Marzo V1,2. Author information Abstract The endocannabinoid signalling system was discovered because receptors in this system are the targets of compounds present in psychotropic preparations of Cannabis sativa. The search for new therapeutics that target endocannabinoid signalling is both challenging and […]

PM 2 site 207

Marijuana and Prescription Pain Reliever Use among Cigarette Smokers.

J Psychoactive Drugs. 2018 Aug 17:1-9. doi: 10.1080/02791072.2018.1506598. [Epub ahead of print] Goldberg RL1,2,3, Cataldo JK1,2,3. Author information Abstract Due to marijuana‘s analgesic effects and its growing national legal status, it is likely that marijuana‘s rising prevalence will impact prescription pain reliever (PPR) use. The present study investigates the relationship between marijuana and PPR use […]

PM 2 site 207

The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.

Eur J Pharmacol. 2018 Aug 16. pii: S0014-2999(18)30473-4. doi: 10.1016/j.ejphar.2018.08.016. [Epub ahead of print] Salaga M1, Binienda A1, Tichkule RB2, Thakur GA3, Makriyannis A2, Storr M4, Fichna J5. Author information Abstract The endocannabinoid system (ECS) plays a crucial role in numerous physiological processes in the central and peripheral nervous systems. In the gastrointestinal (GI) tract, […]

PM 2 site 207

Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system.

Biochem Pharmacol. 2018 Aug 16. pii: S0006-2952(18)30337-X. doi: 10.1016/j.bcp.2018.08.016. [Epub ahead of print] Aymerich MS1, Aso E2, Abellanas MA3, Tolon RM4, Ramos JA5, Ferrer I2, Romero J4, Fernández-Ruiz J5. Author information Abstract The endocannabinoid system (ECS) exerts a modulatory effect of important functions such as neurotransmission, glial activation, oxidative stress, or protein homeostasis. Dysregulation of […]

PM 2 site 207

Revisiting cannabinoid receptor 2 expression and function in murine retina.

Neuropharmacology. 2018 Aug 16. pii: S0028-3908(18)30477-5. doi: 10.1016/j.neuropharm.2018.08.007. [Epub ahead of print] Borowska-Fielding J1, Murataeva N2, Smith B3, Szczesniak AM1, Leishmann E2, Daily L2, Toguri T1, Hillard C4, Romero J5, Bradshaw H2, Kelly M6, Straiker A7. Author information Abstract The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal […]

PM 2 site 207

Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain.

PLoS One. 2018 Aug 16;13(8):e0202566. doi: 10.1371/journal.pone.0202566. eCollection 2018. Bilkei-Gorzo A1, Albayram O1, Ativie F1, Chasan S1, Zimmer T1, Bach K1, Zimmer A1. Author information Abstract Astrocytes, key regulators of brain homeostasis, interact with neighboring glial cells, neurons and the vasculature through complex processes involving different signaling pathways. It is not entirely clear how these […]

PM 2 site 207

Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis.

Medicines (Basel). 2018 Aug 15;5(3). pii: E91. doi: 10.3390/medicines5030091. Gado F1, Digiacomo M2, Macchia M3, Bertini S4, Manera C5. Author information Abstract Recent findings highlight the emerging role of the endocannabinoid system in the control of symptoms and disease progression in multiple sclerosis (MS). MS is a chronic, immune-mediated, demyelinating disorder of the central nervous […]

PM 2 site 207

Cannabinoid signalling in the immature brain: encephalopathies and neurodevelopmental disorders.

Biochem Pharmacol. 2018 Aug 14. pii: S0006-2952(18)30334-4. doi: 10.1016/j.bcp.2018.08.014. [Epub ahead of print] Sagredo O1, Palazuelos J2, Gutierrez-Rodriguez A3, Satta V4, Galve-Roperh I2, Martínez-Orgado J3. Author information Abstract The endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling […]