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Medicinal Cannabinoids in Palliative Care.

Br J Clin Pharmacol. 2018 Jun 20. doi: 10.1111/bcp.13671. [Epub ahead of print] Agar M1,2,3. Author information Abstract The treatment of symptoms in people with palliative diagnoses begins with meticulous clinical assessment with treatment choice (s) selected based on an understanding of the symptom aetiology and the evidence which underpins its treatment. Increasingly the merits […]

Cannabinoid receptor types 1 and 2 and peroxisome proliferator-activated receptor-α: distribution in the skin of clinically healthy cats and cats with hypersensitivity dermatitis.

Vet Dermatol. 2018 Jun 19. doi: 10.1111/vde.12658. [Epub ahead of print] Miragliotta V1, Ricci PL1, Albanese F2, Pirone A1, Tognotti D3, Abramo F1. Author information Abstract BACKGROUND: Cannabinoid receptors and peroxisome proliferator-activated receptor-alpha (PPAR-α) are gaining recognition as potential therapeutic targets for the treatment of skin disorders. HYPOTHESIS/OBJECTIVES: The aim of this study was to […]

Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system

Review Article | Published: 19 June 2018 Ruiqing Ni, Linjing Mu & Simon Ametamey Acta Pharmacologica Sinica (2018) | Download Citation Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic […]

Endophytes of industrial hemp (Cannabis sativa L.) cultivars: identification of culturable bacteria and fungi in leaves, petioles, and seeds.

Can J Microbiol. 2018 Jun 18:1-17. doi: 10.1139/cjm-2018-0108. [Epub ahead of print] Scott M1,1, Rani M1,1, Samsatly J1,1, Charron JB1,1, Jabaji S1,1. Author information Abstract Plant endophytes are a group of microorganisms that reside asymptomatically within the healthy living tissue. The diversity and molecular and biochemical characterization of industrial hemp-associated endophytes have not been previously […]

Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats.

Psychopharmacology (Berl). 2018 Jun 16. doi: 10.1007/s00213-018-4946-0. [Epub ahead of print] Javadi-Paydar M1, Nguyen JD1, Kerr TM1, Grant Y1, Vandewater SA1, Cole M2, Taffe MA3. Author information Abstract RATIONALE: Previous studies report sex differences in some, but not all, responses to cannabinoids in rats. The majority of studies use parenteral injection; however, most human use […]

Is Cannabis Use Treatment Also Indicated for Patients with Low to Moderate Polysubstance Use.

Eur Addict Res. 2018 Jun 14;24(2):79-87. doi: 10.1159/000488345. [Epub ahead of print] Neumann M1, Bühringer G1,2, Höfler M1, Wittchen HU1,3, Hoch E3. Author information Abstract BACKGROUND: Polysubstance use (PSU) is common among patients with cannabis use (CU) and is related to more severe CU problems. However, it is unclear how PSU predicts CU treatment outcomes […]

Religious Involvement and Marijuana Use for Medical and Recreational Purposes.

J Drug Issues. 2018 Jul;48(3):421-434. doi: 10.1177/0022042618770393. Epub 2018 Apr 21. Burdette AM1, Webb NS1, Hill TD2, Haynes SH3, Ford JA4. Author information Abstract In this article, we use data from the 2016 National Survey on Drug Use and Health (NSDUH) to examine the association between religious involvement and marijuana use for medical and recreational […]

Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study.

Int Forum Allergy Rhinol. 2018 Jun 13. doi: 10.1002/alr.22163. [Epub ahead of print] Corrado A1, Battle M2, Wise SK2, Lee FE1, Guidot DM1, DelGaudio JM2, Molina SA1, Levy JM2. Author information Abstract BACKGROUND: The endocannabinoid system represents a highly conserved, innate signaling network with direct and indirect control of eicosanoid-mediated inflammation. Activation of the type […]

The impact of Cannabidiol treatment on regulatory T-17 Cells and neutrophil polarization in Acute Kidney Injury.

Am J Physiol Renal Physiol. 2018 Jun 13. doi: 10.1152/ajprenal.00112.2018. [Epub ahead of print] Baban B1, Hoda MN2, Malik A3, Khodadadi H3, Simmerman E, Vaibhav K4, Mozaffari MS3. Author information Abstract Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils […]

Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis.

Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387. [Epub ahead of print] Hill JD1,2, Zuluaga-Ramirez V1, Gajghate S1, Winfield M1, Persidsky Y1,2. Author information Abstract BACKGROUND AND PURPOSE: The cannabinoid system exerts functional regulation of neural stem cell (NSC) proliferation and adult neurogenesis, yet not all effects of cannabinoid-like compounds seen can be attributed to […]