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The impact of Cannabidiol treatment on regulatory T-17 Cells and neutrophil polarization in Acute Kidney Injury.

Am J Physiol Renal Physiol. 2018 Jun 13. doi: 10.1152/ajprenal.00112.2018. [Epub ahead of print] Baban B1, Hoda MN2, Malik A3, Khodadadi H3, Simmerman E, Vaibhav K4, Mozaffari MS3. Author information Abstract Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils […]

The adult motor phenotype of Dravet syndrome is associated with mutation of the STXBP1 gene and responds well to cannabidiol treatment.

Seizure. 2018 Jun 13;60:68-70. doi: 10.1016/j.seizure.2018.06.010. [Epub ahead of print] Álvarez Bravo G1, Yusta Izquierdo A2. Author information Abstract Dravet syndrome is a terrible disease generally caused by mutations of the SCN1A gene. Recently others genes such as STXBP1 have been involved in the pathogenesis of the disease. The STXBP1 mutation in patients with Dravet […]

Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis.

Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387. [Epub ahead of print] Hill JD1,2, Zuluaga-Ramirez V1, Gajghate S1, Winfield M1, Persidsky Y1,2. Author information Abstract BACKGROUND AND PURPOSE: The cannabinoid system exerts functional regulation of neural stem cell (NSC) proliferation and adult neurogenesis, yet not all effects of cannabinoid-like compounds seen can be attributed to […]

Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity.

Eur Neuropsychopharmacol. 2018 Jun 7. pii: S0924-977X(18)30113-5. doi: 10.1016/j.euroneuro.2018.04.004. [Epub ahead of print] Grimm O1, Löffler M2, Kamping S3, Hartmann A2, Rohleder C4, Leweke M4, Flor H2. Author information Abstract Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are two substances from cannabis sativa that have been implicated in the treatment of mental and neurological disorders. We concentrated […]

Cannabidiol did not induce teratogenicity or neurotoxicity in exposed zebrafish embryos.

Chem Biol Interact. 2018 Jun 11. pii: S0009-2797(18)30216-3. doi: 10.1016/j.cbi.2018.06.008. [Epub ahead of print] Valim Brigante TA1, Abe FR2, Zuardi AW3, Hallak JEC3, Crippa JAS3, de Oliveira DP4. Author information Abstract Cannabidiol (CBD) is a non-psychotomimetic compound of the Cannabis sativa that has been used for the treatment of severe epilepsy as well as other […]

Therapeutic potential of medicinal marijuana: an educational primer for health care professionals.

Drug Healthc Patient Saf. 2018 Jun 11;10:45-66. doi: 10.2147/DHPS.S158592. eCollection 2018. Mouhamed Y#1, Vishnyakov A#1, Qorri B#2, Sambi M#2, Frank SS1, Nowierski C1, Lamba A1, Bhatti U1, Szewczuk MR2. Author information Abstract With the proposed Canadian July 2018 legalization of marijuana through the Cannabis Act, a thorough critical analysis of the current trials on the […]

Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats.

Neurosci Lett. 2018 Jun 6. pii: S0304-3940(18)30409-9. doi: 10.1016/j.neulet.2018.06.006. [Epub ahead of print] de Morais H1, Chaves YC1, Waltrick APF1, Jesus CHA1, Genaro K2, Crippa JA2, da Cunha JM1, Zanoveli JM3. Author information Abstract Depression associated with diabetes has been described as a highly debilitating comorbidity. Due to its complex and multifactorial mechanisms, the treatment […]

[Cannabinoids in pain medicine].

Schmerz. 2018 Jun 7. doi: 10.1007/s00482-018-0299-1. [Epub ahead of print] [Article in German] Karst M1. Author information Abstract The endocannabinoid system (ECS) controls a large number of vital functions. Suboptimal tone of the ECS in certain regions of the nervous system may be associated with disorders that are also associated with pain. Pain and inflammation processes […]

The Role of Cannabinoids in the Setting of Cirrhosis.

Medicines (Basel). 2018 Jun 9;5(2). pii: E52. doi: 10.3390/medicines5020052. Dibba P1, Li AA2, Cholankeril G3, Iqbal U4, Gadiparthi C5, Khan MA6, Kim D7, Ahmed A8. Author information Abstract Although the mortality rates of cirrhosis are underestimated, its socioeconomic burden has demonstrated a significant global impact. Cirrhosis is defined by the disruption of normal liver architecture […]

Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells

Iran Biomed J. 2018 Jun 9. [Epub ahead of print] Gholizadeh F1, Ghahremani MH1, Aliebrahimi S2, Shadboorestan A1, Ostad SN1. Author information Abstract BACKGROUND: The prominent hallmark of malignancies is the metastatic spread of cancer cells. Recent studies have reported that the nature of invasive cells could be changed after this phenomenon, causing chemotherapy resistance. […]