JACC Basic Transl Sci. 2019 Sep 23;4(5):625-637. doi: 10.1016/j.jacbts.2019.05.007. eCollection 2019 Sep.
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Abstract
Excessive binge alcohol drinking may adversely affect cardiovascular function. In this study we characterize the detailed hemodynamic effects of an acute alcohol binge in mice using multiple approaches and investigate the role of the endocannabinoid-cannabinoid 1 receptor (CB1-R) signaling in these effects. Acute alcohol binge was associated with elevated levels of cardiac endocannabinoid anandamide and profound cardiovascular dysfunction lasting for several hours and redistribution of circulation. These changes were attenuated by CB1-R antagonist or in CB1-R knockout mice. Our results suggest that a single alcohol binge has profound effects on the cardiovascular system, which involve endocannabinoid-CB1-R signaling.
KEYWORDS: 2-AG, 2-arachidonyl glycerol, AEA, anandamide, CB1-R (CB1), cannabinoid 1 receptor, CB2-R (CB2), cannabinoid2 receptor, EF, ejection fraction, LV, left ventricle, MAP, mean arterial pressure, P-V pressure-volume, PRSW – preload recruitable stroke work, TPR – total peripheral resistance, binge alcohol drinking, cannabinoids, contractility, dP/dtmax, maximal slope of pressure increment, endocannabinoids
Comment in
- The Detrimental Effects of Alcohol and Cannabinoids on Cardiovascular Function. [JACC Basic Transl Sci. 2019]
- PMID: 31768478
- PMCID: PMC6872859
- DOI: 10.1016/j.jacbts.2019.05.007
