Abstract
Amino acid-fermenting Clostridia have undesirable effects in agricultural systems, which can be mitigated by antibiotics, but resistance necessitates alternatives. Here, we demonstrate the efficacy of cannabidiol on growth and ammonia inhibition of five agriculturally relevant Clostridia: Clostridium sporogenes, Peptostreptococcus spp., Clostridioides difficile, Acetoanaerobium sticklandii, and Clostridium aminophilum.
Keywords: Antibiotic alternative, Antimicrobial activity, Cannabidiol, Clostridioides difficile, Clostridium sporogenes, Hyper-ammonia producing bacteria
Published by Elsevier Ltd.
Conflict of interest statement
Declaration of competing interest The authors declare no competing conflicts of interest. All opinions expressed in this paper are the author’s and do not necessarily reflect the policies and views of USDA, DOE, or ORAU/ORISE. Proprietary or brand names are necessary to report factually on available data; however, the USDA neither guarantees nor warrants the standard of the product, and the use of the name by the USDA implies no approval of the product, nor exclusion of others that may be suitable. USDA is an equal opportunity employer.
Similar articles
-
An rRNA approach for assessing the role of obligate amino acid-fermenting bacteria in ruminal amino acid deamination.Appl Environ Microbiol. 1996 Mar;62(3):815-21. doi: 10.1128/aem.62.3.815-821.1996.PMID: 8975611 Free PMC article.
-
Phylogeny of the ammonia-producing ruminal bacteria Peptostreptococcus anaerobius, Clostridium sticklandii, and Clostridium aminophilum sp. nov.Int J Syst Bacteriol. 1993 Jan;43(1):107-10. doi: 10.1099/00207713-43-1-107.PMID: 8427801
-
The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia.mSphere. 2022 Apr 27;7(2):e0092621. doi: 10.1128/msphere.00926-21. Epub 2022 Mar 30.PMID: 35350846 Free PMC article.
-
Ridinilazole: a novel, narrow-spectrum antimicrobial agent targeting Clostridium (Clostridioides) difficile.Lett Appl Microbiol. 2022 Sep;75(3):526-536. doi: 10.1111/lam.13664. Epub 2022 Feb 11.PMID: 35119124 Free PMC article. Review.
-
Battling Enteropathogenic Clostridia: Phage Therapy for Clostridioides difficile and Clostridium perfringens.Front Microbiol. 2022 Jun 13;13:891790. doi: 10.3389/fmicb.2022.891790. eCollection 2022.PMID: 35770172 Free PMC article. Review.