Canna~Fangled Abstracts

Cannabinoid system of dorsomedial telencephalon modulates behavioral responses to noxious stimulation in the fish Leporinus macrocephalus.

By July 25, 2017No Comments
Physiol Behav. 2017 Jul 25. pii: S0031-9384(17)30229-9. doi: 10.1016/j.physbeh.2017.07.027.
[Epub ahead of print]

Abstract

PM 2 site 207Fish dorsomedial telencephalon has been considered a pallial region homologous to mammals amygdala, being considered a possible substrate for nociception modulation in this animal group. The present study aimed to evaluate the participation of the cannabinoidsystem of Dm telencephalon on nociception modulation in the fish Leporinus macrocephalus. We demonstrated that cannabidiol microinjection in Dm telecephalon inhibits the behavioral nociceptive response to the subcutaneous injection of 3% formaldehyde, and this antinociception is blocked by previous treatment with AM251 microinjection. Furthermore, AM251 microinjection in Dm prior to restraint stress also blockades the stress-induced antinociception. These results reinforce the hypothesis that this pallial telencephalic structure has a pivotal role in nociception modulation in fish.

KEYWORDS:

Amygdala; CB1; Cannabidiol; Nociception

PMID: 28754268

 

DOI: 10.1016/j.physbeh.2017.07.027

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