Encapsulation of cannabinoid drugs in nanostructured lipid carriers.

2016 Mar 4. pii: S0939-6411(16)30081-9. doi: 10.1016/j.ejpb.2016.03.005. [Epub ahead of print]

Esposito E1, Drechsler M2, Cortesi R1, Nastruzzi C3.

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Abstract

This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.
Copyright © 2016. Published by Elsevier B.V.

KEYWORDS:

Cannabinoid drugs; Cryo-TEM; Nanostructured lipid carriers

PMID:: 26952905; [PubMed – as supplied by publisher]

Encapsulation of cannabinoid drugs in nanostructured lipid carriers.

Author information

Abstract

KEYWORDS:

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