Canna~Fangled Abstracts

Endocannabinoids: A protective receptor pool.

By June 11, 2014 No Comments
2014 Jun 11. doi: 10.1038/nrn3772. [Epub ahead of print]

pm8Endocannabinoids: A protective receptor pool.

PMID: 24917301 [PubMed – as supplied by publisher]

Nature Reviews Neuroscience

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NATURE REVIEWS NEUROSCIENCE | RESEARCH HIGHLIGHT

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ENDOCANNABINOIDS

Front cover of the current issue of Nature Reviews NeuroscienceA protective receptor pool

Nature Reviews Neuroscience

 
doi:10.1038/nrn3772

Published online

 

Endocannabinoids have neuroprotective effects in animal models of neurodegenerative disorders, but the underlying mechanism has remained unclear. Guzmán and colleagues now show that the presence of CB1 cannabinoid receptors (CB1Rs) at the terminals of glutamatergic corticostriatal neurons prevents excitotoxicity in the striatum and thereby has neuroprotective effects in a mouse…

References

  1. Chiarlone, A. et al. A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1400988111 (2014)

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