Canna~Fangled Abstracts

Endocannabinoids, Related Compounds and Their Metabolic Routes.

By October 28, 2014 No Comments
 2014 Oct 24;19(11):17078-17106.

pm1Endocannabinoids, Related Compounds and Their Metabolic Routes.

Abstract

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.
PMID:

 

25347455

 

[PubMed – as supplied by publisher]
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