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Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer.

By July 23, 2019 August 10th, 2019 No Comments
2019 Jul 23;9:660. doi: 10.3389/fonc.2019.00660. eCollection 2019.

Author information

1
Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
2
Department of Physics, University of Massachusetts Lowell, Lowell, MA, United States.
3
Department of Biology, University of Massachusetts Boston, Boston, MA, United States.
4
Department of CaNCURE Program, Northeastern University, Boston, MA, United States.
5
Flavocure Biotech Inc., Baltimore, MD, United States.

Abstract

Pancreatic cancer is particularly refractory to modern therapies, with a 5-year survival rate for patients at a dismal 8%. One of the significant barriers to effective treatment is the immunosuppressive pancreatic tumor microenvironment and development of resistance to treatment. New treatment options to increase both the survival and quality of life of patients are urgently needed. This study reports on a new non-cannabinoid, non-psychoactive derivative of cannabis, termed FBL-03G, with the potential to treat pancreatic cancer. In vitro results show major increase in apoptosis and consequential decrease in survival for two pancreatic cancer models- Panc-02 and KPC pancreatic cancer cells treated with varying concentrations of FBL-03G and radiotherapy. Meanwhile, in vivo results demonstrate therapeutic efficacy in delaying both local and metastatic tumor progression in animal models with pancreatic cancer when using FBL-03G sustainably delivered from smart radiotherapy biomaterials. Repeated experiments also showed significant (P < 0.0001) increase in survival for animals with pancreatic cancer compared to control cohorts. The findings demonstrate the potential for this new cannabis derivative in the treatment of both localized and advanced pancreatic cancer, providing impetus for further studies toward clinical translation.

KEYWORDS: cannabis, flavonoids, metastasis, pancreatic cancer, radiotherapy, smart biomaterials

PMID: 31396485
PMCID: PMC6663976
DOI: 10.3389/fonc.2019.00660

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