2015 Mar 4. pii: S1198-743X(15)00313-4. doi: 10.1016/j.cmi.2015.02.021. [Epub ahead of print]
Coppola N1, Zampino R2, Bellini G3, Stanzione M4, Capoluongo N5, Marrone A2, Macera M5, Pasquale G5, Boemio A2, Maione S3, Adinolfi LE2, Del Giudice EM6, Sagnelli E5, Rossi F6.
Abstract
The impact of the cannabinoid receptor 2 (CB2) rs35761398 polymorphism on chronic hepatitis B (CHB) was evaluated in 106 consecutive biopsy proven CHB patients naive for antiviral therapy. A histological activity index (HAI) >9 (Ishak scoring) was more frequent in patients with CB2-63 RR than in those with CB2-63 QR or QQ (37% vs.16.7%, p<0.05). The logistic regression analysis identified CB2-63 RR (p<0.05) and a fibrosis score > 4 (p<0.005) as independently associated with an HAI >9. The observation that the CB2-63 RR variant is an independent predictor of extensive necroinflammation opens up new prospects in the study of CHB.Copyright © 2015. Published by Elsevier Ltd.
KEYWORDS:
Chronic hepatitis B; HBV infection; cannabinoid receptor 2; cannabinoid system; liver disease
- PMID:
- 25749560
- [PubMed – as supplied by publisher]
