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Canna~Fangled Abstracts

Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function.

By July 19, 2013No Comments

pm2Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function.

Source

Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD 20892-9410, USA. hykim@nih.gov

Abstract

Docosahexaenoylethanolamide, the structural analog of the endogenous cannabinoid receptor ligand anandamide, is synthesized from docosahexaenoic acid (DHA) in the brain. Although docosahexaenoylethanolamide binds weakly to cannabinoid receptors, it stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at concentrations of 10-100 nM. We have previously proposed the term synaptamide for docosahexaenoylethanolamide to emphasize its potent synaptogenic activity and structural similarity to anandamide. Synaptamide is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites. The brain synaptamide content is dependent on the dietary DHA intake, suggesting an endogenous mechanism whereby diets containing adequate amounts of omega-3 fatty acids improve synaptogenesis in addition to well-recognized anti-inflammatory effects.
Published by Elsevier Ltd.
PMID:

 

22959887

 

[PubMed – indexed for MEDLINE] 
PMCID:

 

PMC3541447
 [Available on 2014/1/1]

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