2014 Jun 18. pii: jbc.M114.561761. [Epub ahead of print]
Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling.
Moreno E1, Andradas C2, Medrano M1, Caffarel MM2, Pérez-Gómez E2, Blasco-Benito S2, Gómez-Cañas M2, Pazos MR2,Irving AJ3, Lluís C1, Canela EI1, Fernández-Ruiz J2, Guzmán M2, McCormick PJ1, Sánchez C4.
Abstract
The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. As a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here, we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
Copyright © 2014, The American Society for Biochemistry and Molecular Biology.
Copyright © 2014, The American Society for Biochemistry and Molecular Biology.
KEYWORDS:
G protein-coupled receptor (GPCR); cancer; cannabinoid; cannabinoid receptor; signal transduction
- PMID:
- 24942731
- [PubMed – as supplied by publisher]
