Canna~Fangled Abstracts

The Endocannabinoid System in Caenorhabditis elegans

By August 17, 2021August 18th, 2021No Comments
. 2021 Aug 17.

doi: 10.1007/112_2021_64.

Online ahead of print.
Rubén Estrada-Valencia 1 2, María Eduarda de Lima 1, Aline Colonnello 1, Edgar Rangel-López 1, Nariani Rocha Saraiva 3, Daiana Silva de Ávila 3, Michael Aschner 4, Abel Santamaría 5
Affiliations 

Abstract

The existence of a formal Endocannabinoid System in C. elegans has been questioned due to data showing the absence of typical cannabinoid receptors in the worm; however, the presence of a full metabolism for endocannabinoids, alternative ligands, and receptors for these agents and a considerable number of orthologous and homologous genes regulating physiological cannabinoid-like signals and responses – several of which are similar to those of mammals – demonstrates a well-structured and functional complex system in nematodes. In this review, we describe and compare similarities and differences between the Endocannabinoid System in mammals and nematodes, highlighting the basis for the integral study of this novel system in the worm.

 

Keywords: Caenorhabditis elegans, Cannabinoid receptors, Endocannabinoid system, Endocannabinoids, N-acylphosphatidylethanolamine, Nematodes

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