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Canna~Fangled Abstracts

Thermal isomerization of cannabinoid analogues.

By July 22, 2013No Comments

pm2Thermal isomerization of cannabinoid analogues.

Source

Department of Chemistry, University of California, Riverside, California 92521, USA.

Abstract

Thermal isomerization of CBC(an) to THC(an) [nonaromatic analogues of plant cannabinoidscannabichromene (CBC) and Delta(1)-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THC(an), although nonaromatic, has a CB(1) receptor binding affinity similar to that of natural THC.
PMID:

 19919138
[PubMed – indexed for MEDLINE]

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Abstract ImageThermal isomerization of CBCan to THCan [nonaromatic analogues of plant cannabinoids cannabichromene (CBC) and Δ1-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THCan, although nonaromatic, has a CB1 receptor binding affinity similar to that of natural THC.
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