Original Research
Article first published online: 23 MAR 2015
DOI: 10.1111/jsm.12866
© 2015 International Society for Sexual Medicine
Issue
The Journal of Sexual Medicine
Early View (Online Version of Record published before inclusion in an issue)
Keywords:
- Ejaculatory Dysfunctions;
- Lifelong Delayed Ejaculation;
- Sluggish Male Rat;
- Endocannabinoids;
- Anandamide;
- CB1 Receptors
Abstract
Introduction
The sexually sluggish (SLG) male rat has been proposed as an animal model for the study of lifelong delayed ejaculation, a sexual dysfunction for which no treatment is available. Low endocannabinoid anandamide (AEA) doses facilitate sexual behavior display in normal sexually active and in noncopulating male rats through the activation of CB1 receptors.