Abstract
BACKGROUND:
Modulation of the endocannabinoid (eCB) transmission is a promising approach to treating epilepsy. Animal models can be used to investigate this approach. Krushinsky-Molodkina (KM) rats have, genetically, audiogenic epilepsy. Moreover, in these animals, repeated induction of audiogenic seizures results in a progressive prolongation of the seizures, known as audiogenic kindling.
METHODS:
The present study evaluated, in these KM rats, acute and long-term effects of a single dose of 4mg/kg of the cannabinoid-receptor agonist WIN55,212-2.
RESULTS:
Administration of the single dose of WIN55,212-2 one hour before the 4th seizure delayed the kindling process by two weeks, without any acute effect on the audiogenic seizures.
CONCLUSIONS:
This result suggests that short-term potentiation of the eCB system might modify the epileptogenic disease process in patients with a progressive course of epilepsy.
Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
KEYWORDS:
Audiogenic seizures; Endocannabinoid; Epileptogenesis; Kindling; WIN55,212-2
- PMID:
- 25933961
- [PubMed – in process]
