2014 Jul;2(4):313-8. doi: 10.1002/mgg3.69. Epub 2014 Feb 24.
Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population.
Ando T1, Tamura N2, Mera T3, Morita C4, Takei M5, Nakamoto C6, Koide M7, Hotta M8, Naruo T9, Kawai K4,Nakahara T10, Yamaguchi C11, Nagata T12, Ookuma K13, Okamoto Y14, Yamanaka T15, Kiriike N16,Ichimaru Y17, Ishikawa T2, Komaki G18; Japanese Genetic Research Group For Eating Disorders.
Abstract
The functional c.385C>A single-nucleotide polymorphism (SNP) in the fatty acid amide hydrolase (FAAH) gene, one of the major degrading enzymes of endocannabinoids, is reportedly associated with anorexia nervosa (AN). We genotyped the c.385C>A SNP (rs324420) in 762 lifetime AN and 605 control participants in Japan. There were significant differences in the genotype and allele frequencies of c.385C>A between the AN and control groups. The minor 385A allele was less frequent in the AN participants than in the controls (allele-wise, odds ratio = 0.799, 95% confidence interval [CI] 0.653-0.976, P = 0.028). When the cases were subdivided into lifetime restricting subtype AN and AN with a history of binge eating or purging, only the restricting AN group exhibited a significant association (allele-wise, odds ratio = 0.717, 95% CI 0.557-0.922, P = 0.0094). Our results suggest that having the minor 385A allele of the FAAH gene may be protective against AN, especially restricting AN. This finding supports the possible role of the endocannabinoid system in susceptibility to AN.
KEYWORDS:
Anandamide; cannabinoid 1 receptor; eating disorder; endocannabinoid
- PMID:
- 25077173
- [PubMed]
