Acute Δ9-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice.
Department of Psychology, West Virginia University, Morgantown, WV USA. Electronic address: email@example.com.
Copyright © 2013. Published by Elsevier B.V.
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- Fig. 1. THC dose-dependently attenuates diclofenac-induced gastric hemorrhages. THC was administered intraperitoneally (i.p.) or orally (p.o.) 1 h before diclofenac sodium (100 mg/kg, p.o.) was administered in fasted mice. Data presented as mean±S.E.M. (n=7–8). Open circles: intraperitoneal Δ9-THC; closed circles: oral Δ9-THC.*P<0.05,**P<0.01 vs. vehicle pretreatment. All mice were treated with diclofenac.
- Fig. 2. Representative images of mouse stomachs. Vehicle or Δ9-THC (1 mg/kg, i.p. or 5 mg/kg, p.o.) was administered 1 h before diclofenac sodium (100 mg/kg, p.o.) was administered in fasted mice. Yellow arrows indicate hemorrhagic streaks. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
- Fig. 3. Dose-response curves of Δ9-THC sensitive behaviors. Δ9-THC was administered (i.p. or p.o.), and then assessed 1 h later in a battery of tests highly sensitive to the pharmacological effects of cannabinoids, including (A) spontaneous locomotor activity (B) catalepsy, (C) analgesia in the tail immersion test, and (D) hypothermia. Data presented as mean±S.E.M. (n=8–12). Open circles: intraperitoneal Δ9-THC; closed circles: oral Δ9-THC. *P<0.05,**P<0.01 vs. vehicle.
- Table 1. ED50 (95% confidence limit) values and potency ratios (95% C.L.) of Δ9-THC (mg/kg) in blocking diclofenac-induced gastric hemorrhages and in the tetrad cannabinoid test battery. Mice were treated with Δ9-THC and were either treated with diclofenac to induce gastric hemorrhages or were screened in a cannabinoid sensitive test battery.
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