Archive | March, 2008

Antineoplastic and apoptotic effects of cannabinoids. N-acylethanolamines: protectors or killers?

 2008 Mar;30(1):6-21. Antineoplastic and apoptotic effects of cannabinoids. N-acylethanolamines: protectors or killers? Pushkarev VM1, Kovzun OI, Tronko MD. Author information Abstract The proapoptotic and antineoplastic properties of cannabinoids with emphasis on effects of N-acylethanolamines were analyzed. Cannabinoids enhanced apoptotic and necrotic processes in many types of tumour cells and tissues. Involvement of different types of receptors and […]

Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells

Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells Fabio Cianchi1, Laura Papucci2, Nicola Schiavone2, Matteo Lulli2, Lucia Magnelli2, Maria Cristina Vinci3, Luca Messerini4, Clementina Manera6, Elisa Ronconi5, Paola Romagnani5, Martino Donnini2, Giuliano Perigli1, Giacomo Trallori1, Elisabetta Tanganelli2, Sergio Capaccioli2 and Emanuela Masini3 +Author Affiliations Authors’ Affiliations: Departments of 1Medical and […]

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC Feb 4, 2008. Published in final edited form as: Am J Physiol Heart Circ Physiol. Jul 2007; 293(1): H610–H619. Published online Mar 23, 2007. doi:  10.1152/ajpheart.00236.2007 PMCID: PMC2228254 NIHMSID: NIHMS38117 Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption Mohanraj Rajesh,1 Partha Mukhopadhyay,1 Sándor Bátkai,1 György Haskó,2 Lucas Liaudet,3 Viktor R. Drel,4Irina G. […]

Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.

2008 Mar 15;68(6):1945-52. doi: 10.1158/0008-5472.CAN-07-5176. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Blázquez C1, Salazar M, Carracedo A, Lorente M, Egia A, González-Feria L, Haro A, Velasco G, Guzmán M. Author information Abstract Cannabinoids, the active components of Cannabis sativa L. and their derivatives, inhibit tumor growth in laboratory animals by inducing apoptosis of tumor cells and impairing tumor angiogenesis. […]