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Anticancer mechanisms of cannabinoids.

  Journal List > Curr Oncol > v.23(Suppl 2); 2016 Mar > PMC4791144 Curr Oncol. 2016 Mar; 23(Suppl 2): S23–S32.  Published online 2016 Mar 16. doi:  10.3747/co.23.3080 PMCID: PMC4791144 Anticancer mechanisms of cannabinoids G. Velasco, PhD,*†‡ C. Sánchez, PhD,*§ and  M. Guzmán, PhD*†‖ Author information ► Copyright and License information ► Go to: Abstract In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body […]

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Autism Spectrum Disorders: Potential Neuro-Psychopharmacotherapeutic Plant-Based Drugs.

Assay Drug Dev Technol. 2018 Nov 14. doi: 10.1089/adt.2018.848. [Epub ahead of print] Urdaneta KE1, Castillo MA1, Montiel N2, Semprún-Hernández N1, Antonucci N3, Siniscalco D4,5. Author information Abstract Over the years, scientific researches have validated the healing benefits of many psychopharmacotherapeutic plant-based drugs to ameliorate psychiatric disorders. In contrast, the use of chemical procedures to […]

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The protective effects of Δ9 -tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia.

J Pharm Pharmacol. 2018 Nov 14. doi: 10.1111/jphp.13042. [Epub ahead of print] Beydogan AB1, Coskun ZM2, Bolkent S1. Author information Abstract OBJECTIVES: A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ9 –tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to […]

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Cannabis, cannabinoids and the endocannabinoid system – is there therapeutic potential for inflammatory bowel disease?

J Crohns Colitis. 2018 Nov 12. doi: 10.1093/ecco-jcc/jjy185. [Epub ahead of print] Ambrose T1,2, Simmons A1,2. Author information Abstract Cannabis sativa and its extracts have been used for centuries both medicinally and recreationally. There is accumulating evidence that exogenous cannabis and related cannabinoids improve symptoms associated with inflammatory bowel disease such as pain, loss of […]

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Chemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopy.

BMC Plant Biol. 2018 Nov 12;18(1):275. doi: 10.1186/s12870-018-1481-4. Ebersbach P1, Stehle F2, Kayser O3, Freier E4. Author information Abstract BACKGROUND: Cannabis possesses a rich spectrum of phytochemicals i.e. cannabinoids, terpenes and phenolic compounds of industrial and medicinal interests. Most of these high-value plant products are synthesised in the disk cells and stored in the secretory […]

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Medical Cannabis: A plurimillennial history of an evergreen.

J Cell Physiol. 2018 Nov 11. doi: 10.1002/jcp.27725. [Epub ahead of print] Pisanti S1, Bifulco M2. Author information Abstract The history of Cannabis goes along that of humankind, as speculated based on geographical and evolutionary models together with historic data collected to date. Its medical use is several thousand years old, as attested both by […]

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Pain and Depression: A Systematic Review.

Harv Rev Psychiatry. 2018 Nov/Dec;26(6):352-363. doi: 10.1097/HRP.0000000000000198. IsHak WW1, Wen RY, Naghdechi L, Vanle B, Dang J, Knosp M, Dascal J, Marcia L, Gohar Y, Eskander L, Yadegar J, Hanna S, Sadek A, Aguilar-Hernandez L, Danovitch I, Louy C. Author information Abstract BACKGROUND: Pain comorbid with depression is frequently encountered in clinical settings and often […]

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Investigational small molecules in phase II clinical trials for the treatment of epilepsy: cannabidivarin, selurampanel (BGG492) and ganaxolone.

Expert Opin Investig Drugs. 2018 Nov 8. doi: 10.1080/13543784.2018.1543398. [Epub ahead of print] Greco M1, Varriale G1, Coppola G2, Operto F2, Verrotti A1, Iezzi ML1. Author information Abstract Epilepsy is a neurological disorder that significantly impacts the quality of life of the affected person and affects approximately 70 million people globally. Despite advances in research, […]

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A physical and genetic map of Cannabis sativa identifies extensive rearrangement at the THC/CBD acid synthase locus.

Genome Res. 2018 Nov 8. pii: gr.242594.118. doi: 10.1101/gr.242594.118. [Epub ahead of print] Laverty KU1, Stout JM2, Sullivan MJ3, Shah H4, Gill N5, Holbrook L6, Deikus G4, Sebra R4, Hughes TR1, Page JE7, van Bakel H8. Author information Abstract Cannabis sativa is widely cultivated for medicinal, food, industrial, and recreational use, but much remains unknown […]

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Medical cannabis: A needs analysis for people with epilepsy.

Complement Ther Clin Pract. 2018 Nov;33:43-48. doi: 10.1016/j.ctcp.2018.08.003. Epub 2018 Aug 8. Kerai A1, Sim TF1, Emmerton L2. Author information Abstract BACKGROUND AND PURPOSE: Medical cannabis may be effective treatment for refractory epilepsy. It is timely to seek users’ and potential users’ opinions in regard to its place in the management of epilepsy. MATERIALS AND […]

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Association of Cannabinoid Administration With Experimental Pain in Healthy Adults: A Systematic Review and Meta-analysis.

JAMA Psychiatry. 2018 Nov 1;75(11):1118-1127. doi: 10.1001/jamapsychiatry.2018.2503. De Vita MJ1, Moskal D1, Maisto SA1, Ansell EB1,2. Author information Abstract IMPORTANCE: Cannabinoid drugs are widely used as analgesics, but experimental pain studies have produced mixed findings. The analgesic properties of cannabinoids remain unclear. OBJECTIVE: To conduct a systematic review and meta-analysis of the association between cannabinoid […]