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Anticancer mechanisms of cannabinoids.

  Journal List > Curr Oncol > v.23(Suppl 2); 2016 Mar > PMC4791144 Curr Oncol. 2016 Mar; 23(Suppl 2): S23–S32.  Published online 2016 Mar 16. doi:  10.3747/co.23.3080 PMCID: PMC4791144 Anticancer mechanisms of cannabinoids G. Velasco, PhD,*†‡ C. Sánchez, PhD,*§ and  M. Guzmán, PhD*†‖ Author information ► Copyright and License information ► Go to: Abstract In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body […]

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∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor.

Forensic Toxicol. 2019;37(1):207-214. doi: 10.1007/s11419-018-0457-2. Epub 2018 Nov 24. Kimura T1, Takaya M1, Usami N1, Watanabe K2, Yamamoto I1. Author information Abstract PURPOSE: ∆9 –Tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), major psychoactive constituents of marijuana, induce potentiation of pentobarbital-induced sleep in mice. We have elucidated the mechanism of enhancement of the anesthetic effect of pentobarbital by […]

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A Novel Role for the Endocannabinoid System in Ameliorating Motivation for Alcohol Drinking and Negative Behavioral Affect Following Traumatic Brain Injury in Rats.

J Neurotrauma. 2019 Jan 14. doi: 10.1089/neu.2018.5854. [Epub ahead of print] Fucich EA1,2, Mayeux JP1,3, McGinn MA1,4, Gilpin NW1,5, Edwards S1,6, Molina P7,8. Author information Abstract Traumatic brain injury (TBI) is associated with psychiatric dysfunction-including pain, cognitive impairment, anxiety, and increased alcohol use. We previously demonstrated that inhibiting endocannabinoid degradation post-TBI with JZL184 attenuates neuroinflammation […]

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Latitudinal Adaptation and Genetic Insights Into the Origins of Cannabis sativa L.

Front Plant Sci. 2018 Dec 21;9:1876. doi: 10.3389/fpls.2018.01876. eCollection 2018. Zhang Q1, Chen X1, Guo H1, Trindade LM2, Salentijn EMJ2, Guo R1, Guo M1, Xu Y1, Yang M1. Author information Abstract Cannabis is one of the most important industrial crops distributed worldwide. However, the phylogeographic structure and domestication knowledge of this crop remains poorly understood. […]

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Do Endocannabinoids Regulate Glucose Reabsorption in the Kidney?

Nephron. 2019 Jan 11:1-4. doi: 10.1159/000494512. [Epub ahead of print] Hinden L, Tam J. Abstract Diabetic nephropathy (DN), a distinct manifestation of diabetic kidney disease, affects approximately 30% of patients with diabetes. While most attention has been focused on glomerular changes related to DN, there is growing evidence that tubulopathy is a key feature in […]

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MicroRNA-29a Attenuates Diabetic Glomerular Injury through Modulating Cannabinoid Receptor 1 Signaling.

Molecules. 2019 Jan 11;24(2). pii: E264. doi: 10.3390/molecules24020264. Tung CW1,2, Ho C3,4, Hsu YC5,6, Huang SC7, Shih YH8,9, Lin CL10,11,12,13,14. Author information Abstract Diabetic nephropathy often leads to end-stage renal disease and life-threatening morbidities. Simple control of risk factors is insufficient to prevent the progression of diabetic nephropathy, hence the need for discovering new treatments […]

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Cannabis and Turmeric as Complementary Treatments for IBD and Other Digestive Diseases.

Curr Gastroenterol Rep. 2019 Jan 11;21(2):2. doi: 10.1007/s11894-019-0670-0. Quezada SM1, Cross RK2. Author information Abstract PURPOSE OF REVIEW: Complementary therapies for inflammatory bowel disease (IBD) have earned growing interest from patients and investigators alike, with a dynamic landscape of research in this area. In this article, we review results of the most recent studies evaluating […]

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Understanding the evidence for medical cannabis and cannabis-based medicines for the treatment of chronic non-cancer pain.

Eur Arch Psychiatry Clin Neurosci. 2019 Jan 11. doi: 10.1007/s00406-018-0960-9. [Epub ahead of print] Campbell G1, Stockings E2, Nielsen S3. Author information Abstract The use of medical cannabis and cannabis-based medicines has received increasing interest in recent years; with a corresponding surge in the number of studies and reviews conducted in the field. Despite this […]

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The effects of cannabinoids on the endocrine system.

Endokrynol Pol. 2018;69(6):705-719. doi: 10.5603/EP.a2018.0072. Borowska M, Czarnywojtek A, Sawicka-Gutaj N, Woliński K1, Płazińska MT, Mikołajczak P, Ruchała M. Author information Abstract Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds […]

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Analysis of Terpenes in Cannabis sativa L. Using GC/MS: Method Development, Validation, and Application.

Planta Med. 2019 Jan 15. doi: 10.1055/a-0828-8387. [Epub ahead of print] Ibrahim EA1,2, Wang M1, Radwan MM1,3, Wanas AS1,4, Majumdar CG1, Avula B1, Wang YH1, Khan IA1,5, Chandra S1, Lata H1, Hadad GM2, Abdel Salam RA2, Ibrahim AK6, Ahmed SA6, ElSohly MA1,7. Author information Abstract Terpenes are the major components of the essential oils present […]

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Cannabidiol in Anxiety and Sleep: A Large Case Series.

Perm J. 2019;23. pii: 18-041. doi: 10.7812/TPP/18-041. Shannon S1, Lewis N2, Lee H3, Hughes S4. Author information Abstract CONTEXT: Cannabidiol (CBD) is one of many cannabinoid compounds found in cannabis. It does not appear to alter consciousness or trigger a “high.” A recent surge in scientific publications has found preclinical and clinical evidence documenting value […]