Archive | August, 2010

Phylogenetic analysis of lipid mediator GPCRs.

2010;24:116-26. Phylogenetic analysis of lipid mediator GPCRs. Mizutani S, Tanaka M, Wheelock CE, Kanehisa M, Goto S. Author information Abstract Lipid mediator is the collective term for prostanoids, leukotrienes, lysophospholipids, platelet-activating factor, endocannabinoids and other bioactive lipids, that are involved in various physiological functions including inflammation, immune regulation and cellular development. They act by binding to their ligand-specific G-protein coupled receptors (GPCRs). Since 1990’s a number […]

Dendritic Cell Regulation by Cannabinoid-Based Drugs

Pharmaceuticals (Basel). Aug 2010; 3(8): 2733–2750.  Published online Aug 23, 2010. doi:  10.3390/ph3082733 PMCID: PMC4033947 Dendritic Cell Regulation by Cannabinoid-Based Drugs Mattias Svensson,* Puran Chen, and  Oscar Hammarfjord Author information ► Article notes ► Copyright and License information ► Go to: Abstract Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have […]

Dendritic Cell Regulation by Cannabinoid-Based Drugs.

2010 Aug 23;3(8):2733-2750. Svensson M1, Chen P2, Hammarfjord O3. Author information Abstract Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and cancer, as well as neuroinflammatory and chronic inflammatory diseases. Moreover, […]

Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease.

 2010 Aug;215(8):611-6. doi: 10.1016/j.imbio.2009.09.007. Epub 2009 Oct 14. Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. O’Sullivan SE1, Kendall DA. Author information  Abstract Cannabinoids act via cell surface G protein-coupled receptors (CB(1) and CB(2)) and the ion channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is the peroxisome […]

Cannabinoids and Dementia: A Review of Clinical and Preclinical Data.

 2010 Aug 17;3(8):2689-2708. Walther S1, Halpern M2. Author information Abstract The endocannabinoid system has been shown to be associated with neurodegenerative diseases and dementia. We review the preclinical and clinical data on cannabinoids and four neurodegenerative diseases: Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD) and vascular dementia (VD). Numerous studies have demonstrated an involvement […]

The Role of Cannabinoid Receptors in the Descending Modulation of Pain

Pharmaceuticals (Basel). Aug 2010; 3(8): 2661–2673.  Published online Aug 16, 2010. doi:  10.3390/ph3082661 PMCID: PMC4033943 The Role of Cannabinoid Receptors in the Descending Modulation of Pain Enza Palazzo,* Livio Luongo, Vito de Novellis, Francesco Rossi, and  Sabatino Maione Author information ► Article notes ► Copyright and License information ► Go to: Abstract The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose […]

The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism

Pharmaceuticals (Basel). Aug 2010; 3(8): 2647–2660.  Published online Aug 13, 2010. doi:  10.3390/ph3082647 PMCID: PMC4033942 The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism Marcel Jenny,1 Sebastian Schröcksnadel,2 Florian Überall,1 and  Dietmar Fuchs2,* Author information ► Article notes ► Copyright and License information ► Go to: Abstract Phytocannabinoids present in Cannabis plants are well known to exert potent anti-inflammatory and immunomodulatory effects. Previously, […]

Brain CB₂ Receptors: Implications for Neuropsychiatric Disorders.

2010 Aug 10;3(8):2517-2553. Roche M1, Finn DP2. Author information Abstract Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB₂ receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB₂ receptor in the brain is significantly lower than that of the CB₁ receptor. […]

Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.

Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats. Hill AJ, Weston SE, Jones NA, Smith I, Bevan SA, Williamson EM, Stephens GJ, Williams CM, Whalley BJ. Source School of Pharmacy, University of Reading, Whiteknights, Reading, Berkshire, UK. Abstract PURPOSE: We assessed the anticonvulsant potential of the phytocannabinoid Δ⁹-tetrahydrocannabivarin (Δ⁹-THCV) by investigating its effects in an in vitro piriform cortex (PC) […]