Archive | September, 2010

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.

Carcinogenesis. Sep 2010; 31(9): 1584–1591. Published online Jul 25, 2010. doi:  10.1093/carcin/bgq151 PMCID: PMC2930808 Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines Iain Brown,* Maria G. Cascio,1 Klaus W.J. Wahle, Reem Smoum,2 Raphael Mechoulam,2 Ruth A. Ross,1 Roger G. Pertwee,1 and Steven D. Heys Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles […]

Expression of cannabinoid receptors in human kidney.

2010 Sep;25(9):1133-8. Expression of cannabinoid receptors in human kidney. Larrinaga G1, Varona A, Pérez I, Sanz B, Ugalde A, Cándenas ML, Pinto FM, Gil J, López JI. Author information Abstract The presence of CB1 and CB2 cannabinoid receptors and their physiological role in the kidney has been described in animal models but not in humans. Our aim in this study was to evaluate the presence of […]

Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells.

 2010 Sep 15;80(6):846-57. doi: 10.1016/j.bcp.2010.05.010. Epub 2010 May 19. Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells. Ramer R1, Hinz B. Author information Abstract Cannabinoids have received considerable attention as potential antiglaucomatous drugs. Recently, prostaglandins (PG) have been suggested to contribute to this effect. Within the […]

Tissue Engineering of Cartilage; Can Cannabinoids Help?

Pharmaceuticals (Basel). Sep 2010; 3(9): 2970–2985.  Published online Sep 6, 2010. doi:  10.3390/ph3092970 PMCID: PMC4034107 Tissue Engineering of Cartilage; Can Cannabinoids Help? Aoife Gowran,1,* Katey McKayed,1,2 Manoj Kanichai,1 Cillian White,1 Nissrin Hammadi,1 and  Veronica Campbell1,2 Author information ► Article notes ► Copyright and License information ► Go to: Abstract This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid […]

Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting.

2010 Sep 3;3(9):2930-2955. Darmani NA1. Author information Abstract Chemotherapy-induced nausea and vomiting (CINV) is a complex pathophysiological condition and consists of two phases. The conventional CINV neurotransmitter hypothesis suggests that the immediate phase is mainly due to release of serotonin (5-HT) from the enterochromaffin cells in the gastrointestinal tract (GIT), while the delayed phase is […]

From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System.

2010 Sep 2;3(9):2910-2929. Bambang KN1, Karasu T2, Gebeh A3, Taylor AH4, Marczylo TH5, Lam P6, Willets JM7, Konje JC8. Author information Abstract There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been shown to be one of the […]

ORPHAN ENDOGENOUS LIPIDS AND ORPHAN GPCRS: A GOOD MATCH

Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2010 September 1. Published in final edited form as: Prostaglandins Other Lipid Mediat. 2009 September; 89(3-4): 131–134. Published online 2009 April 18. doi:  10.1016/j.prostaglandins.2009.04.006 PMCID: PMC2740803 NIHMSID: NIHMS111546 ORPHAN ENDOGENOUS LIPIDS AND ORPHAN GPCRS: A GOOD MATCH Heather B Bradshaw,1,2 Sung Ha Lee,1 and Douglas McHugh1 Author information ► Copyright and License information ► The publisher’s final edited […]