Archive | June, 2013

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B. Source Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany. Abstract The antitumorigenic mechanism of cannabidiol is still controversial. This study investigates the role of COX-2 and PPAR-γ in cannabidiol’s proapoptotic and tumor-regressive action. In […]

Characterization of Cannabis sativa allergens.

Epub 2013… Characterization of Cannabis sativa allergens. Nayak AP, Green BJ, Sussman G, Berlin N, Lata H, Chandra S, Elsohly MA, Hettick JM, Beezhold DH. Source Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Abstract BACKGROUND: Allergic sensitization to Cannabis sativa is rarely reported, but the increasing consumption of marijuana […]

Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: Synthesis and neuropharmacology.

 [Epub ahead of print] Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: Synthesis and neuropharmacology. Yogeeswari P, Sharma M, Samala G, Gangadhar M, Karthick S, Mallipeddi S, Semwal A, Sriram D. Source Neuropathic Pain Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science – Pilani, Hyderabad Campus, R.R. District, 500078 Andhra Pradesh, India. Electronic address: pyogee@hyderabad.bits-pilani.ac.in. Abstract […]

Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling.

Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. Keimpema E, Alpár A, Howell F, Malenczyk K, Hobbs C, Hurd YL, Watanabe M, Sakimura K, Kano M, Doherty P,Harkany T. Source Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. Abstract Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic […]

Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations.

 [Epub ahead of print] Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Siegmund SV, Wojtalla A, Schlosser M, Zimmer A, Singer MV. Source Dept. of Medicine I, University Hospital Bonn, Bonn, Germany; Dept. of Medicine II (Gastroenterology, Hepatology & Infectious Diseases), University Hospital Mannheim, University […]

Micro extraction by packed sorbent coupled to liquid chromatography tandem mass spectrometry for the rapid and sensitive determination of cannabinoids in oral fluids.

[Epub ahead of print] Micro extraction by packed sorbent coupled to liquid chromatography tandem mass spectrometry for the rapid and sensitive determination of cannabinoids in oral fluids. Sergi M, Montesano C, Odoardi S, Mainero Rocca L, Fabrizi G, Compagnone D, Curini R. Source Department of Food Sciences, University of Teramo, 64100 Teramo, Italy. Electronic address: msergi@unite.it. Abstract The evaluation of oral fluids (OFs) […]

Cannabinoid Receptors and Signal Transduction

Cannabinoid Receptors and Signal Transduction Allyn C. Howlett and Joong-Youn Shim. The cannabinoid receptors are members of the rhodopsin-like family of 7-transmembrane spanning receptors that are believed to bind their agonist ligands within the central core formed by the interaction of the seven transmembrane helices. Cannabinoid receptors are associated with G proteins of the Gi/o […]

Anandamide-derived prostamide F2α negatively regulates adipogenesis.

[Epub ahead of print] Anandamide-derived prostamide F2α negatively regulates adipogenesis. Silvestri C, Martella A, Poloso NJ, Piscitelli F, Capasso R, Izzo A, Woodward DF, Di Marzo V. Source Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R., Italy; Abstract Lipid mediators variedly affect adipocyte differentiation. Anandamide stimulates adipogenesis via CB1 receptors and PPARG. Anandamide may be converted by PTGS2 (COX2) and prostaglandin F […]

Quantification of endocannabinoids in postmortem brain of schizophrenic subjects.

[Epub ahead of print] Quantification of endocannabinoids in postmortem brain of schizophrenic subjects. Muguruza C, Lehtonen M, Aaltonen N, Morentin B, Meana JJ, Callado LF. Source Department of Pharmacology, University of the Basque Country UPV/EHU, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain. Abstract Numerous studies have implicated the endocannabinoid system in the pathophysiology of schizophrenia.Endocannabinoids have been measured in blood […]

DIFFERENTIAL DRUG-DRUG INTERACTIONS OF THE SYNTHETIC CANNABINOIDS JWH-018 AND JWH-073: IMPLICATIONS FOR DRUG ABUSE LIABILITY AND PAIN THERAPY.

[Epub ahead of print] DIFFERENTIAL DRUG-DRUG INTERACTIONS OF THE SYNTHETIC CANNABINOIDS JWH-018 AND JWH-073: IMPLICATIONS FOR DRUG ABUSE LIABILITY AND PAIN THERAPY. Brents LK, Zimmerman SM, Saffell AR, Prather PL, Fantegrossi WE. Source University of Arkansas for Medical Sciences. Abstract Marijuana substitutes often contain blends of multiple psychoactive synthetic cannabinoids (SCBs), including the prevalent SCBs […]