Archive | February, 2014

Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries.

2014 Feb 28. [Epub ahead of print] Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. Baranowska-Kuczko M1, Kozłowska H, Kozłowski M, Schlicker E, Kloza M, Surażyński A, Grzęda E, Malinowska B. Author information Abstract Endocannabinoids contract, relax or do not affect vessels with different calibre and tone in the pulmonary circulation in four species. The aim of the […]

Barriers to access for Canadians who use cannabis for therapeutic purposes.

 2014 Feb 28. pii: S0955-3959(14)00033-4. doi: 10.1016/j.drugpo.2014.02.009. [Epub ahead of print] Barriers to access for Canadians who use cannabis for therapeutic purposes. Belle-Isle L1, Walsh Z2, Callaway R3, Lucas P4, Capler R5, Kay R6, Holtzman S2. Author information Abstract BACKGROUND: There is increased interest in the therapeutic potential of cannabis in recent decades. Canada, the Netherlands, Israel and some states in the United States have […]

Effect of N-Arachidonoyl Dopamine on Activity of Neuronal Network in Primary Hippocampus Culture upon Hypoxia Modelling.

2014 Feb;156(4):461-4. doi: 10.1007/s10517-014-2374-7. Epub 2014 Mar 5. Effect of N-Arachidonoyl Dopamine on Activity of Neuronal Network in Primary Hippocampus Culture upon Hypoxia Modelling. Vedunova MV1, Mitroshina EV, Sakharnova TA, Bobrov MY, Bezuglov VV, Khaspekov LG, Mukhina IV. Author information Abstract We studied the effect of endocannabinoid N-arachidonoyl dopamine on spontaneous bioelectric activity of cultured hippocampal neurons in a model of […]

Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress.

2014 Feb 26. pii: S0166-4328(14)00102-8. doi: 10.1016/j.bbr.2014.02.027. [Epub ahead of print] Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress. Martire SI1, Maniam J2, South T2, Holmes N1, Westbrook RF1, Morris MJ3. Author information Abstract Like people, rodents exposed […]

Impaired Neurogenesis by HIV-1-Gp120 is Rescued by genetic deletion of Fatty Acid Amide Hydrolase Enzyme.

2014 Feb 26. doi: 10.1111/bph.12657. [Epub ahead of print] Impaired Neurogenesis by HIV-1-Gp120 is Rescued by genetic deletion of Fatty Acid Amide Hydrolase Enzyme. Avraham HK1, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Wood J, Wang L, Masliah E, Avraham S. Author information Abstract BACKGROUND/PURPOSE: The HIV-envelope glycoprotein Gp120 is involved in neuronal injury and is associated with neuro-AIDS pathogenesis in the […]

Endocannabinoids in Synaptic Plasticity and Neuroprotection.

2014 Feb 25. [Epub ahead of print] Endocannabinoids in Synaptic Plasticity and Neuroprotection. Xu JY1, Chen C. Author information Abstract Endocannabinoids (eCBs) are endogenous lipid mediators involved in a variety of physiological, pharmacological, and pathological processes. While activation of the eCB system primarily induces inhibitory effects on both GABAergic and glutamatergic synaptic transmission and plasticity through acting on presynaptically expressed […]

Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.

2014 Feb 27. [Epub ahead of print] Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats. Kwilasz AJ1, Abdullah RA, Poklis JL, Lichtman AH, Negus SS. Author information Abstract Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty […]

A Critical Role for Prefrontocortical Endocannabinoid Signaling in the Regulation of Stress and Emotional Behavior.

 2014 Feb 25. pii: S0149-7634(14)00027-X. doi: 10.1016/j.neubiorev.2014.02.006. [Epub ahead of print] A Critical Role for Prefrontocortical Endocannabinoid Signaling in the Regulation of Stress and Emotional Behavior. McLaughlin RJ1, Hill MN2, Gorzalka BB3. Author information Abstract The prefrontal cortex (PFC) provides executive control of the brain in humans and rodents, coordinating cognitive, emotional, and behavioral responses to threatening stimuli and […]

Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function.

 2014 Feb 25;5:75. eCollection 2014. Front Immunol. 2014; 5: 75.  Published online Feb 25, 2014. Prepublished online Jan 8, 2014. doi:  10.3389/fimmu.2014.00075 PMCID: PMC3933826 Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function Anna Nicolaou,1,* Claudio Mauro,2 Paula Urquhart,1 and  Federica Marelli-Berg2 Author information ► Article notes ► Copyright and License information ► Go to: Abstract Fatty acids are involved in T cell biology both as nutrients important […]

Update on the role of spinal cord TRPV1 receptors in pain modulation.

2014 Feb 24;63 Suppl 1:S225-36. Update on the role of spinal cord TRPV1 receptors in pain modulation. Spicarova D1, Nerandzic V, Palecek J. Author information 1Department of Functional Morphology, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic. palecek@biomed.cas.cz. Abstract The structure, expression and function of the transient receptor potential vanilloid 1 (TRPV1) […]