Archive | July, 2014

Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain.

 2014 Jul 31. doi: 10.1002/jnr.23461. [Epub ahead of print] Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain. Martins DF1, Brito RN, Stramosk J, Batisti AP, Madeira F, Turnes BL, Mazzardo-Martins L, Santos AR,Piovezan AP. Author information Abstract Water immersion is widely used in physiotherapy and might relieve pain, probably by activating several distinct somatosensory modalities, including […]

Activity of anandamide (AEA) metabolic enzymes in rat placental bed.

2014 Jul 31. pii: S0890-6238(14)00199-3. doi: 10.1016/j.reprotox.2014.07.078. [Epub ahead of print] Activity of anandamide (AEA) metabolic enzymes in rat placental bed. Fonseca BM1, Battista N2, Correia-da-Silva G3, Rapino C4, Maccarrone M5, Teixeira NA6. Author information Abstract Endocannabinoids are endogenous lipid mediators, with anandamide (AEA) being the first member identified. It is now widely accepted that AEA influences early pregnancy events and its levels, […]

[The interaction between serotonergic and cannabinoidergic modulations involved in the fear extinction].

2013 Jun;33(3):95-9. [The interaction between serotonergic and cannabinoidergic modulations involved in the fear extinction]. [Article in Japanese] Yoshida T, Kano M, Watanabe M, Yoshioka M. Abstract In the amygdala, it has been demonstrated that cannabinoid CB1 receptors are particularly enriched in GABAergic axon terminals and moderately expressed on glutamatergic fibers, and involved in the fear coping strategies. In this study, […]

Rheumatologists lack confidence in their knowledge of cannabinoids pertaining to the management of rheumatic complaints.

 2014 Jul 30;15(1):258. [Epub ahead of print] BMC Musculoskelet Disord. 2014; 15: 258.  Published online Jul 30, 2014. doi:  10.1186/1471-2474-15-258 PMCID: PMC4121007 Rheumatologists lack confidence in their knowledge of cannabinoids pertaining to the management of rheumatic complaints Mary-Ann Fitzcharles,1,2 Peter A Ste-Marie,2,3 Daniel J Clauw,3 Shahin Jamal,4 Jacob Karsh,5 Sharon LeClercq,6Jason J McDougall,7 Yoram Shir,2 Kam Shojania,4,8 and  Zach Walsh9 Author information ► Article notes ► Copyright and License information ► Go […]

Chemotherapy induced peripheral neuropathic pain

Korean J Anesthesiol. Jul 2014; 67(1): 4–7.  Published online Jul 29, 2014. doi:  10.4097/kjae.2014.67.1.4 PMCID: PMC4121493 Chemotherapy induced peripheral neuropathic pain Hue Jung Park Author information ► Article notes ► Copyright and License information ► Go to: Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most serious complications associated with anticancer drugs. CIPN leads to a lower quality of life and dysfunction […]

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability.

Research Article   Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability ACS ActiveView PDFHi-Res Print, Annotate, Reference QuickView PDF [7299 KB] PDF w/ Links[620 KB] Full Text HTML Abstract Supporting Info -> Figures Reference QuickView Add to […]

Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex.

2014 Jul 28. doi: 10.1111/jnc.12839. [Epub ahead of print] Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex. Hiebel C1, Kromm T, Stark M, Behl C. Author information Abstract Cannabinoid Receptor 1 (CB1) has been initially described as the receptor for Delta-9-Tetrahydrocannabinol in the central nervous system (CNS), mediating retrograde synaptic signaling of the endocannabinoid system. Beside […]

Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway.

2014 Jul 25. pii: S0300-9084(14)00205-3. doi: 10.1016/j.biochi.2014.07.014. [Epub ahead of print] Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. Signorello MG1, Leoncini G2. Author information Abstract The endocannabinoid 2-arachidonoylglycerol (2-AG) can be considered a true agonist as it is able to activate human platelets stimulating arachidonic acid release, […]

Dynamics and plasticity of spinal locomotor circuits.

 2014 Jul 22;29C:133-141. doi: 10.1016/j.conb.2014.06.016. [Epub ahead of print] Dynamics and plasticity of spinal locomotor circuits. El Manira A. Author information Abstract Spinal circuits generate coordinated locomotor movements. These hardwired circuits are supplemented with neuromodulation that provide the necessary flexibility for animals to move smoothly through their environment. This review will highlight some recent insights […]

Inhibition of Endocannabinoid Metabolism by the Metabolites of Ibuprofen and Flurbiprofen.

 2014 Jul 25;9(7):e103589. doi: 10.1371/journal.pone.0103589. eCollection 2014. Inhibition of Endocannabinoid Metabolism by the Metabolites of Ibuprofen and Flurbiprofen. Karlsson J, Fowler CJ. Author information Abstract BACKGROUND: In addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) by cyclooxygenase-2 (COX-2) and fatty acid […]