Archive | November, 2014

Mn-SOD Upregulation by Electroacupuncture Attenuates Ischemic Oxidative Damage via CB1R-Mediated STAT3 Phosphorylation.

 2014 Nov 29. [Epub ahead of print] Mn-SOD Upregulation by Electroacupuncture Attenuates Ischemic Oxidative Damage via CB1R-Mediated STAT3 Phosphorylation. Sun S1, Chen X, Gao Y, Liu Z, Zhai Q, Xiong L, Cai M, Wang Q. Author information  Abstract Electroacupuncture (EA) pretreatment elicits the neuroprotective effect against cerebral ischemic injury through cannabinoid receptor type 1 receptor (CB1R). In current study, we aimed to investigate whether […]

Cannabis smoking and serum C-reactive protein: A quantile regressions approach based on NHANES 2005-2010.

2014 Nov 28. pii: S0376-8716(14)01929-2. doi: 10.1016/j.drugalcdep.2014.11.017. [Epub ahead of print] Cannabis smoking and serum C-reactive protein: A quantile regressions approach based on NHANES 2005-2010. Alshaarawy O1, Anthony JC2. Author information Abstract BACKGROUND: Pre-clinical studies link cannabinoid-1 receptor activation to inflammation and atherosclerotic effects; anti-inflammation and immunosuppression seem to be mediated by cannabinoid-2 receptor activation. In this epidemiological […]

“Disease Modifying Nutricals” for multiple sclerosis.

 2014 Nov 27. pii: S0163-7258(14)00215-0. doi: 10.1016/j.pharmthera.2014.11.015. [Epub ahead of print] “Disease Modifying Nutricals” for multiple sclerosis. Schmitz K1, Barthelmes J1, Stolz L1, Beyer S1, Diehl O1, Tegeder I2. Author information  Abstract The association between vitamin D and multiple sclerosis has (re)-opened new interest in nutrition and natural compounds in the prevention and treatment of this neuroinflammatory disease. The dietary […]

Cannabinoid CB1 receptors mediate the effects of dipyrone.

 2014 Nov 27. doi: 10.1111/1440-1681.12347. [Epub ahead of print] Cannabinoid CB1 receptors mediate the effects of dipyrone. Crunfli F1, Vilela FC, Giusti-Paiva A. Author information  Abstract Dipyrone is a non-steroidal anti-inflammatory drug (NSAID) used primarily as an analgesic and antipyretic. Some hypothesize that dipyrone activity can modulate other pathways, including endocannabinoid signaling. Thus, the aim of this study […]

Medical marijuana in neurology.

2014 Dec;14(12):1453-1465. Medical marijuana in neurology. Benbadis SR1, Sanchez-Ramos J, Bozorg A, Giarratano M, Kalidas K, Katzin L, Robertson D, Vu T, Smith A, Zesiewicz T. Author information  Abstract Constituents of the Cannabis plant, cannabinoids, may be of therapeutic value in neurologic diseases. The most abundant cannabinoids are Δ9-tetrahydrocannabinol, which possesses psychoactive properties, and cannabidiol, which has no intrinsic psychoactive effects, but exhibits neuroprotective properties in preclinical […]

Truffles contain endocannabinoid metabolic enzymes and anandamide.

 2014 Nov 26. pii: S0031-9422(14)00495-6. doi: 10.1016/j.phytochem.2014.11.012. [Epub ahead of print] Truffles contain endocannabinoid metabolic enzymes and anandamide. Pacioni G1, Rapino C2, Zarivi O1, Falconi A3, Leonardi M1, Battista N4, Colafarina S1, Sergi M5, Bonfigli A1, Miranda M1, Barsacchi D5, Maccarrone M6. Author information  Abstract Truffles are the fruiting body of fungi, members of the Ascomycota phylum endowed with major gastronomic and commercial value. The development […]

Genetic Disruption of 2-Arachidonoylglycerol Synthesis Reveals a Key Role for Endocannabinoid Signaling in Anxiety Modulation.

2014 Nov 26. pii: S2211-1247(14)00955-3. doi: 10.1016/j.celrep.2014.11.001. [Epub ahead of print] Genetic Disruption of 2-Arachidonoylglycerol Synthesis Reveals a Key Role for Endocannabinoid Signaling in Anxiety Modulation. Shonesy BC1, Bluett RJ2, Ramikie TS2, Báldi R3, Hermanson DJ4, Kingsley PJ4, Marnett LJ4, Winder DG5, Colbran RJ6, Patel S7. Author information  Abstract Endocannabinoid (eCB) signaling has been heavily implicated in the modulation of anxiety and depressive behaviors and emotional learning. […]

New mechanisms and perspectives in nicotine withdrawal.

 2014 Nov 26. pii: S0028-3908(14)00425-0. doi: 10.1016/j.neuropharm.2014.11.009. [Epub ahead of print] New mechanisms and perspectives in nicotine withdrawal. Jackson KJ1, Muldoon PP2, De Biasi M3, Damaj MI4. Author information  Abstract Diseases associated with tobacco use constitute a major health problem worldwide. Upon cessation of tobacco use, an unpleasant withdrawal syndrome occurs in dependent individuals. Avoidance of the negative […]

Comparative study of the functional properties of lupin, green pea, fava bean, hemp, and buckwheat flours as affected by pH.

2014 Nov;2(6):802-810. Epub 2014 Oct 7. Comparative study of the functional properties of lupin, green pea, fava bean, hemp, and buckwheat flours as affected by pH. Raikos V, Neacsu M, Russell W, Duthie G. Author information  Abstract The demand for products of high nutritional value from sustainable sources is growing rapidly in the global food market. In this study, […]

Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ9-tetrahydrocannabinol in Sprague-Dawley rats.

[Epub ahead of print] Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ9-tetrahydrocannabinol in Sprague-Dawley rats. Taffe MA1, Creehan KM, Vandewater SA. Author information  Abstract BACKGROUND AND PURPOSE: Growing evidence shows cannabidiol (CBD) modulates some effects of Δ9 -tetrahydrocannabinol (THC). CBD is a constituent of some strains of recreational cannabis but content is highly variable. High CBD strains may […]