Archive | January, 2015

The Effectiveness of Cannabinoids in the Management of Chronic Nonmalignant Neuropathic Pain: A Systematic Review.

2015 Winter;29(1):7-14. doi: 10.11607/ofph.1274. Boychuk DG, Goddard G, Mauro G, Orellana MF. Abstract Aims: To carry out a systematic review to assess the effectiveness of cannabis extracts and cannabinoids in the management of chronic nonmalignant neuropathic pain. Methods: Electronic database searches were performed using Medline, PubMed, Embase, all evidence-based medicine reviews, and Web of Science, through communication with the Canadian […]

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

2015 Jan 28. pii: S0960-894X(15)00051-7. doi: 10.1016/j.bmcl.2015.01.039. [Epub ahead of print] Del Prete D1, Caprioglio D1, Appendino G1, Minassi A2, Schiano-Moriello A3, Di Marzo V3, De Petrocellis L4. Author information Abstract Replacement of the benzylamide motif of synthetic capsaicin (nonivamide, 1c) with a tetrazole moiety was detrimental for TRPV1 binding, but unexpectedly generated a potent and non-electrophilic TRPA1 agonist (4a). Spurred […]

ALTERATIONS IN THE MEDULLARY ENDOCANNABINOID SYSTEM CONTRIBUTE TO AGE-RELATED IMPAIRMENT OF BAROREFLEX SENSITIVITY.

2015 Jan 29. [Epub ahead of print] Schaich CL1, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Author information Abstract As they age, Sprague-Dawley (SD) rats develop elevated systolic blood pressure associated with impaired baroreflex sensitivity (BRS) for control of heart rate. We previously demonstrated in young hypertensive (mRen2)27 rats that impaired BRS is restored by CB1 cannabinoid receptor […]

Blunted Cardiac Response to Hemorrhage in Cirrhotic Rats is Mediated by Local Macrophage-Released Endocannabinoids.

 2015 Jan 29. pii: S0168-8278(15)00052-5. doi: 10.1016/j.jhep.2015.01.021. [Epub ahead of print] Gaskari SA1, Liu H1, D’Mello C1, Kunos G2, Lee SS3. Author information Abstract BACKGROUND/AIMS: Cirrhosis is associated with blunted cardiovascular response to stimuli such as hemorrhage, but the mechanism remains unclear. We aimed to clarify the role of endocannabinoids in blunted hemorrhage response in cirrhotic rats. METHODS: Cirrhosis […]

Sativex in the management of multiple sclerosis-related spasticity: role of the corticospinal modulation.

2015;2015:656582. doi: 10.1155/2015/656582. Epub 2015 Jan 29. Russo M1, Calabrò RS1, Naro A1, Sessa E1, Rifici C1, D’Aleo G1, Leo A1, De Luca R1, Quartarone A2, Bramanti P1. Author information Abstract Sativex is an emergent treatment option for spasticity in patients affected by multiple sclerosis (MS). This oromucosal spray, acting as a partial agonist at cannabinoid receptors, may modulate the balance between excitatory and inhibitory neurotransmitters, […]

Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ9-tetrahydrocannabinol (THC).

2015 Jan 28. pii: S0376-6357(15)00042-X. doi: 10.1016/j.beproc.2015.01.014. [Epub ahead of print] Olarte-Sánchez CM1, Valencia-Torres L2, Cassaday HJ3, Bradshaw CM4, Szabadi E5. Author information Abstract Rat’s performance on a progressive-ratio schedule maintained by sucrose (0.6M, 50μl) and corn oil (100%, 25μl) reinforcers was assessed using a model derived from Killeen’s (1994) theory of scheduled-controlled behaviour, ‘Mathematical Principles of Reinforcement’. When […]

N-stearoyltyrosine protects primary cortical neurons against Aβ(1-40)-induced injury through inhibiting endocannabinoid degradation.

2015 Jan 28. pii: S0024-3205(15)00052-1. doi: 10.1016/j.lfs.2015.01.012. [Epub ahead of print] Cui H1, Yang R1, Liu S1, Fu G2, Lu Y3. Author information Abstract AIMS: N-stearoyltyrosine (NsTyr) as an anandamide (AEA) analogue has close relationships with AEA not only in structure but also in terms of biological actions of endocannbinoids. Since β-amyloid (Aβ)-induced primary neuronal injury involves the activation […]

Cannabinoid CB2 receptor agonist AM1241 attenuates microglial activation by modulating the activated state in N9 microglia exposed to LPS plus IFNγ

2015 Jan 27. pii: S0006-291X(15)00103-5. doi: 10.1016/j.bbrc.2015.01.073. [Epub ahead of print] Ma L1, Jia J1, Liu X2, Bai F1, Wang Q3, Xiong L4. Author information Abstract Inhibition of microglial activation is effective in treating various neurological disorders. Activation of microglial cannabinoid CB2 receptor induces anti-inflammatory effects, and the mechanism, however, is still elusive. Microglia could be activated into the classic activated state […]

Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice.

2015 Jan 27. pii: S0306-4522(15)00085-8. doi: 10.1016/j.neuroscience.2015.01.030. [Epub ahead of print] Rahimi A1, Faizi M1, Talebi F2, Noorbakhsh F3, Naderi N1. Author information Abstract Cannabinoids have recently been approved to exert broad anti-inflammatory activities in experimental models of multiple sclerosis (MS). It has been demonstrated that these compounds could also have effects on neurodegeneration, demyelination, and autoimmune processes occurring in […]

Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 (CB1 ) receptors located on glutamatergic neurons and on astrocytes.

2015 Jan 27. doi: 10.1111/jnc.13044. [Epub ahead of print] Belluomo I1, Matias I, Pernègre C, Marsicano G, Chaouloff F. Author information Abstract This study examined the respective influences of cannabinoid type-1 (CB1 ) receptors expressed either in forebrain GABAergic neurons, in cortical glutamatergic neurons or in astrocytes on the turnover rates of the endocannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabinoid N-acylethanolamides, […]