Archive | February, 2015

Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory Synapses.

2015 Feb 28;2(2). pii: e0029-14.2015. Zhao L1, Yeh ML1, Levine ES1. Author information Abstract The endogenous cannabinoid (endocannabinoid) system is an important regulator of synaptic function. Endocannabinoids acutely modulate inhibitory and excitatory transmission, and also mediate long-term depression at GABAergic and glutamatergic synapses. Typically, endocannabinoid synthesis and release is stimulated by depolarization-induced calcium influx and/or activation of phospholipase-C (PLC) […]

The potential of inhibitors of endocannabinoid metabolism as anxiolytic and antidepressive drugs-A practical view.

2015 Feb 28. pii: S0924-977X(15)00038-3. doi: 10.1016/j.euroneuro.2015.02.005. [Epub ahead of print] Fowler CJ1. Author information Abstract The endocannabinoid system, comprising cannabinoid CB1 and CB2 receptors, their endogenous ligands anandamide and 2-arachidonoylglyerol, and their synthetic and metabolic enzymes, are involved in many biological processes in the body, ranging from appetite to bone turnover. Compounds inhibiting the breakdown of anandamide and […]

Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury.

 2015 Feb 27. [Epub ahead of print] Mann A1, Smoum R, Trembovler V, Alexandrovich A, Breuer A, Mechoulam R, Shohami E. Author information Abstract The endocannabinoid (eCB) system helps recovery following traumatic brain injury (TBI). Treatment with 2-arachidonoylglycerol (2-AG), a cerebral eCB ligand, was found to ameliorate the secondary damage. Interestingly, the fatty acid amino acid amide (FAAA) N-arachidonoyl-L-serine (AraS) exerts similar eCB […]

Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge.

[Epub ahead of print] Nass SR1, Long JZ, Schlosburg JE, Cravatt BF, Lichtman AH, Kinsey SG. Author information 1Department of Psychology, West Virginia University, Morgantown, WV, 26506, USA. Abstract Cannabinoid receptor agonists, such as Δ9-THC, the primary active constituent of Cannabis sativa, have anti-pyrogenic effects in a variety of assays. Recently, attention has turned to the endogenous cannabinoid system and how endocannabinoids, including […]

Endocannabinoid transport revisited.

 2015;98:441-85. doi: 10.1016/bs.vh.2014.12.011. Epub 2015 Feb 27. Nicolussi S1, Gertsch J2. Author information Abstract Endocannabinoids are arachidonic acid-derived endogenous lipids that activate the endocannabinoid system which plays a major role in health and disease. The primary endocannabinoids are anandamide (AEA, N-arachidonoylethanolamine) and 2-arachidonoyl glycerol. While their biosynthesis and metabolism have been studied in detail, it remains unclear how endocannabinoids are transported across the […]

Emerging targets and therapeutic approaches for the treatment of osteoarthritis pain.

2015 Feb 27. [Epub ahead of print] Rahman W1, Dickenson AH. Author information Abstract PURPOSE OF REVIEW: Osteoarthritis is a complex and often painful disease that is inadequately controlled with current analgesics. This review discusses emerging targets and therapeutic approaches that may lead to the development of better analgesics. RECENT FINDINGS: Aberrant excitability in peripheral and […]

Decreased circulating anandamide levels in preeclampsia.

 2015 Feb 26. doi: 10.1038/hr.2015.20. [Epub ahead of print] Molvarec A1, Fügedi G1, Szabó E2, Stenczer B1, Walentin S3, Rigó J Jr1. Author information Abstract The endocannabinoid system has a key role in female reproduction, including implantation, decidualization and placentation. A growing number of studies indicate that placental and peripheral blood anandamide levels correlate closely with both spontaneous miscarriage and ectopic pregnancy. […]

Marijuana: A Time-Honored but Untested Treatment for Epilepsy.

 2015 Feb 26:1-4. [Epub ahead of print] McLachlan RS1. Author information Abstract The biology of the endocannabinoid system in the brain provides a possible basis for a beneficial pharmacological effect of marijuana on seizures. However, evidence for efficacy of cannabis treatment of epilepsy is anecdotal because no acceptable randomized controlled trials have been done. Proper dosage and […]

Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice.

2015 Feb 24. pii: jpet.115.222836. [Epub ahead of print] Hruba L1, Seillier A1, Zaki A1, Cravatt BF2, Lichtman AH3, Giuffrida A1, McMahon LR4. Author information Abstract Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) inhibitors exert pre-clinical effects indicative of therapeutic potential (i.e., analgesia). However, the extent to which MAGL and FAAH inhibitors produce unwanted effects remains unclear. Here, FAAH […]

Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy.

2015 Apr;67(2):209-16. doi: 10.1016/j.pharep.2014.08.023. Epub 2014 Sep 16. Bujalska-Zadrożny M1, de Cordé A2, Pawlik K2. Author information Abstract BACKGROUND: Influence of a relatively specific inhibitor cyclooxygenase (COX)-2, celecoxib, a relatively specific inhibitor of neuronal nitric oxide synthase (NOS), 7-Ni, and a relatively selective inhibitor of inducible NOS, L-NIL, on the action of a preferentially selective CB1 cannabinoid receptor agonist, […]