Archive | July, 2015

Cannabinoid receptor expression in the bladder is altered in detrusor overactivity.

2015 Jul 30. [Epub ahead of print] Bakali E1, McDonald J, Elliott RA, Lambert DG, Tincello DG. Author information Abstract INTRODUCTION: Immunohistochemical (IHC) evidence shows that cannabinoid receptors (CB) are expressed in human bladders and cannabinoid agonists are known to inhibit detrusor contractility. However, the mechanism for this inhibition remains unknown. In addition, the role of CB in detrusor overactivity (DO) is under-investigated. […]

The GPR55 antagonist CID16020046 protects against intestinal inflammation.

2015 Jul 30. doi: 10.1111/nmo.12639. [Epub ahead of print] Stančić A1, Jandl K1, Hasenöhrl C1, Reichmann F1, Marsche G1, Schuligoi R1, Heinemann A1, Storr M2, Schicho R1. Author information Abstract BACKGROUND: G protein-coupled receptor 55 (GPR55) is a lysophospholipid receptor responsive to certain cannabinoids. The role of GPR55 in inflammatory processes of the gut is largely unknown. Using the recently characterized GPR55 inhibitor CID16020046, we […]

Tetrahydrocannabinol in Behavioral Disturbances in Dementia: A Crossover Randomized Controlled Trial.

2015 Jul 30. pii: S1064-7481(15)00225-0. doi: 10.1016/j.jagp.2015.07.011. [Epub ahead of print] van den Elsen GA1, Ahmed AI2, Verkes RJ3, Feuth T4, van der Marck MA5, Olde Rikkert MG5. Author information Abstract OBJECTIVES: Neuropsychiatric symptoms (NPS) are highly prevalent in dementia, but effective pharmacotherapy without important side effects is lacking. This study aims to assess the efficacy and safety of oral tetrahydrocannabinol (THC) […]

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats.

2015 Jul 29. pii: S0924-977X(15)00233-3. doi: 10.1016/j.euroneuro.2015.07.015. [Epub ahead of print] Carnevali L1, Vacondio F2, Rossi S3, Callegari S4, Macchi E3, Spadoni G5, Bedini A5, Rivara S2, Mor M2, Sgoifo A6. Author information Abstract In humans, depression is often triggered by prolonged exposure to psychosocial stressors and is often associated with cardiovascular comorbidity. Mounting evidence suggests a role for endocannabinoid signaling in the regulation of both […]

Cannabinoid Receptor Type 2 (CB2) Dependent and Independent Effects of WIN55,212-2 on Atherosclerosis in Ldlr-null Mice.

 2015 Jul;3(2):53-63. Netherland-Van Dyke C1, Rodgers W2, Fulmer M2, Lahr Z2, Thewke D2. Author information Abstract PURPOSE: WIN55,212-2, a potent synthetic agonist of cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2), reduces atherosclerosis in apolipoprotein E (ApoE) null mice. Although pharmacologic evidence suggests the anti-atherosclerotic effects of WIN55,212-2 are mediated via CB2, this remains to be confirmed by genetic studies. Therefore, in […]

Changes in IGF-I, urinary free cortisol and adipokines during dronabinol therapy in anorexia nervosa: Results from a randomised, controlled trial.

2015 Jul 29. pii: S1096-6374(15)30017-4. doi: 10.1016/j.ghir.2015.07.006. [Epub ahead of print] Andries A1, Frystyk J2, Flyvbjerg A2, Støving RK3. Author information Abstract OBJECTIVE: Anorexia nervosa (AN) is characterised by complex neuroendocrine disturbances due to severe underweight, physical hyperactivity and purging behaviour. Cannabinoid agonists are used to palliate cachexia of various causes, but their interactions with the hormonal systems that are […]

Endocannabinoid Signaling in Autism.

 2015 Jul 28. [Epub ahead of print] Chakrabarti B1, Persico A, Battista N, Maccarrone M. Author information Abstract Autism spectrum disorder (ASD) is a complex behavioral condition with onset during early childhood and a lifelong course in the vast majority of cases. To date, no behavioral, genetic, brain imaging, or electrophysiological test can specifically validate a clinical diagnosis […]

Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions.

 2015 Jul 28;5:12440. doi: 10.1038/srep12440. Ma L1, Jia J1, Niu W2, Jiang T1, Zhai Q1, Yang L1, Bai F1, Wang Q1, Xiong L1. Author information Abstract Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury. Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes (mtCB1R) and involved in regulating mitochondrial functions under physiological conditions. However, whether mtCB1R affords neuroprotection against I/R injury remains […]

[The endocannabinoid system role in the pathogenesis of obesity and depression].

2015 Jul 28;39(229):61-66. [Article in Polish] Zdanowicz A1, Kaźmierczak W2, Wierzbiński P2. Author information Abstract Excessive consumption and obesity do not always have to be strictly pathological. The adjustment of food intake as well as the pleasure of eating are the results of the circulation of neurotransmitters, hormones and glucocorticoids which have an ability to regulate the […]

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.

2015 Jul 22. pii: S2211-1247(15)00725-1. doi: 10.1016/j.celrep.2015.06.075. [Epub ahead of print] Viader A1, Blankman JL2, Zhong P3, Liu X3, Schlosburg JE4, Joslyn CM1, Liu QS3, Tomarchio AJ5, Lichtman AH5, Selley DE5, Sim-Selley LJ5, Cravatt BF6. Author information Abstract The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG signaling is terminated by enzymatic hydrolysis-a reaction that is principally performed by monoacylglycerol […]