Archive | August, 2015

Anandamide and Decidual Remodeling: COX-2 oxidative metabolism as a key regulator.

2015 Aug 31. pii: S1388-1981(15)00165-1. doi: 10.1016/j.bbalip.2015.08.011. [Epub ahead of print] Almada M1, Piscitelli F2, Fonseca BM1, Di Marzo V2, Correia-da-Silva G1, Teixeira N1. Author information Abstract Recently, endocannabinoids have emerged as signaling mediators in reproduction. It is widely accepted that anandamide (AEA) levels must be tightly regulated, and that a disturbance in AEA levels may impact decidual stability and regression. We […]

Displays of dabbing marijuana extracts on YouTube.

2015 Aug 29. pii: S0376-8716(15)01613-0. doi: 10.1016/j.drugalcdep.2015.08.020. [Epub ahead of print] Krauss MJ1, Sowles SJ2, Mylvaganam S3, Zewdie K4, Bierut LJ5, Cavazos-Rehg PA6. Author information Abstract BACKGROUND: Dabbing involves heating marijuana extracts to a high temperature and inhaling the vapor. Little is known about this new method of using marijuana. YouTube, the most popular platform for sharing online videos, may be a […]

Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.

 2015 Aug 29;103:226-237. doi: 10.1016/j.ejmech.2015.08.047. [Epub ahead of print] Dasari R1, De Carvalho A2, Medellin DC1, Middleton KN1, Hague F3, Volmar MN4, Frolova LV5, Rossato MF6, De La Chapa JJ7, Dybdal-Hargreaves NF8, Pillai A9, Kälin RE4, Mathieu V2, Rogelj S5, Gonzales CB7, Calixto JB6, Evidente A10, Gautier M3, Munirathinam G9, Glass R4, Burth P11, Pelly SC12, van Otterlo WA12, Kiss R2, Kornienko A13. Author information Abstract Many types of cancer, including glioma, melanoma, non-small cell lung cancer (NSCLC), among […]

Fatty acids, endocannabinoids and inflammation.

2015 Aug 28. pii: S0014-2999(15)30220-X. doi: 10.1016/j.ejphar.2015.08.051. [Epub ahead of print] Witkamp R1. Author information Abstract From their phylogenetic and pharmacological classification it might be inferred that cannabinoid receptors and their endogenous ligands constitute a rather specialised and biologically distinct signalling system. However, the opposite is true and accumulating data underline how much the endocannabinoid system is […]

Medical Cannabis in Arizona: Patient Characteristics, Perceptions, and Impressions of Medical Cannabis Legalization.

2015 Aug 28:1-8. [Epub ahead of print] Troutt WD1, DiDonato MD. Author information Abstract Many advances have been made toward understanding the benefits of medical cannabis. However, less is known about medical cannabis patients themselves. Prior research has uncovered many important patient characteristics, but most of that work has been conducted with participants in California, who may not represent […]

Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner.

2015 Aug 28. pii: 1403205. [Epub ahead of print] Mai P1, Yang L1, Tian L1, Wang L1, Jia S1, Zhang Y1, Liu X1, Yang L1, Li L2. Author information Abstract Hepatic injury undergoes significant increases in endocannabinoidsand infiltrations of macrophages, yet the concrete mechanisms of changes in endocannabinoids and the functions of macrophage-expressed cannabinoid receptors (CBs) are unclear. Biosynthetic and degradative enzymes of endocannabinoids revealed […]

The Genetic Structure of Marijuana and Hemp.

2015 Aug 26;10(8):e0133292. doi: 10.1371/journal.pone.0133292. Sawler J1, Stout JM2, Gardner KM3, Hudson D4, Vidmar J5, Butler L3, Page JE6, Myles S3. Author information Abstract Despite its cultivation as a source of food, fibre and medicine, and its global status as the most used illicit drug, the genus Cannabis has an inconclusive taxonomic organization and evolutionary history. Drug types of Cannabis (marijuana), which […]

Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol.

2015 Aug 26. pii: S0014-2999(15)30224-7. doi: 10.1016/j.ejphar.2015.08.048. [Epub ahead of print] Petrenko AB1, Yamazaki M2, Sakimura K2, Kano M3, Baba H4. Author information Abstract Monoacylglycerol lipase (MGL) is a major enzyme involved in degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Selective inhibitors of MGL are regarded as promising analgesics and anticancer agents. To gain insight into the possible consequences of […]

Pharmacy Students’ Knowledge and Attitudes Regarding Medical Marijuana.

2015 Aug 25;79(6):85. doi: 10.5688/ajpe79685. Moeller KE1, Woods B1. Author information Abstract Objective. To determine pharmacy students’ knowledge of and attitudes toward medical marijuana and to determine if pharmacy students need additional education on the topic. Methods. Pharmacy students were asked to complete a survey on medical marijuana that assessed their knowledge of, medical uses of, adverse effects with, and attitudes toward medical […]

Pro-inflammatory obesity in aged cannabinoid-2 receptor deficient mice.

2015 Aug 25. doi: 10.1038/ijo.2015.169. [Epub ahead of print] Schmitz K1, Mangels N2, Häussler A1, Ferreirós N1, Fleming I2, Tegeder I1,3. Author information Abstract Background and Objectives: Cannabinoid-1 receptor signaling increases the rewarding effects of food intake and promotes the growth of adipocytes, whereas CB2 possibly opposes these pro-obesity effects by silencing the activated immune cells that are key drivers […]