Archive | July, 2017

Cannabinoid receptor 2-63 RR variant is independently associated with severe necroinflammation in HIV/HCV coinfected patients.

PLoS One. 2017 Jul 31;12(7):e0181890. doi: 10.1371/journal.pone.0181890. eCollection 2017. Sagnelli C1, Uberti-Foppa C2, Hasson H2, Bellini G3, Minichini C1, Salpietro S2, Messina E2, Barbanotti D2, Merli M2, Punzo F3, Coppola N1, Lazzarin A2, Sagnelli E1, Rossi F3. Author information Abstract OBJECTIVE: This is the first study to analyze the impact of the rs35761398 variant of […]

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.

Int J Mol Sci. 2017 Jul 31;18(8). pii: E1669. doi: 10.3390/ijms18081669. Kozela E1,2, Juknat A3,4, Vogel Z5,6. Author information Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their precise regulation is still far from […]

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine.

Int J Mol Sci. 2017 Jul 30;18(8). pii: E1617. doi: 10.3390/ijms18081617. Nagy-Grócz G1,2, Zádor F3, Dvorácskó S4, Bohár Z5,6, Benyhe S7, Tömböly C8, Párdutz Á9, Vécsei L10,11. Author information Abstract Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that […]

The Current Landscape of Marijuana and Pharmacogenetics.

Cureus. 2017 Jul 30;9(7):e1525. doi: 10.7759/cureus.1525. Rambaran KA1, Chu M2, Johnson TB2, Alzghari SK2. Author information Abstract The treatment of medical conditions with cannabis and cannabinoid compounds is advancing. Although there are numerous reports related to the genetic variations of the cannabinoid receptor, a lack of studies that examine the relationship between other pharmacogenetic markers […]

Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition.

Aging Cell. 2017 Jul 28. doi: 10.1111/acel.12638. [Epub ahead of print] Sophocleous A1,2,3, Marino S1,4, Kabir D1, Ralston SH2, Idris AI1,4. Author information Abstract The endocannabinoid system plays a role in regulating bone mass and bone cell activity and inactivation of the type 1 (Cnr1) or type 2 (Cnr2) cannabinoid receptors influences peak bone mass […]

Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.

PLoS One. 2017 Jul 27;12(7):e0182141. doi: 10.1371/journal.pone.0182141. eCollection 2017. Zhang Y1, Kim DK1, Lu Y2, Jung YS1, Lee JM1, Kim YH3, Lee YS1, Kim J4, Dewidar B5, Jeong WI6, Lee IK7,8, Cho SJ4,8, Dooley S5, Lee CH3, Li X2, Choi HS1. Author information Abstract Fibrinogen, 1 of 13 coagulation factors responsible for normal blood clotting, […]

Single oral dose of cannabinoid derivate loaded PLGA nanocarriers relieves neuropathic pain for eleven days.

Nanomedicine. 2017 Jul 26. pii: S1549-9634(17)30140-5. doi: 10.1016/j.nano.2017.07.010. [Epub ahead of print] Berrocoso E1, Rey-Brea R2, Fernández-Arévalo M3, Micó JA1, Martín-Banderas L4. Author information Abstract Neuropathic pain, resistant to opiates and other drugs, is a chronic/persistent state with a complex treatment and often poor efficacy. In this scenario, cannabinoids are increasingly regarded as a genuine […]

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder.

Neuropsychopharmacology. 2017 Jul 26. doi: 10.1038/npp.2017.162. [Epub ahead of print] Hill MN1, Campolongo P2, Yehuda R3, Patel S4,5,6,7. Author information Abstract Exposure to stress is an undeniable, but in most cases surmountable, part of life. However, in certain individuals, exposure to severe or cumulative stressors can lead to an array of pathological conditions including posttraumatic […]

Cannabinoids and the Kidney: Effects in Health and Disease.

Am J Physiol Renal Physiol. 2017 Jul 26:ajprenal.00290.2017. doi: 10.1152/ajprenal.00290.2017. [Epub ahead of print] Park F1, Potukuchi PK2, Moradi H3, Kovesdy CP4. Author information Abstract Consumption of cannabis and various related products (cannabinoids) for both medicinal and recreational use is gaining popularity. Furthermore, regulatory changes are fostering a cultural shift towards increasing liberalization of cannabis […]