Archive | January, 2018

Second-Hand Exposure of Staff Administering Vaporised Cannabinoid Products to Patients in a Hospital Setting.

Drugs R D. 2018 Jan 12. doi: 10.1007/s40268-017-0225-5. [Epub ahead of print] Solowij N1,2, Galettis P3,4, Broyd SJ5, de Krey P4, Martin JH3,4. Author information Abstract BACKGROUND: In many health settings, administration of medicinal cannabis poses significant implementation barriers including drug storage and safety for administering staff and surrounding patients. Different modes of administration also […]

Hedging bets: Applying New Zealand’s gambling machine regime to cannabis legalization.

Int J Drug Policy. 2018 Jan 11;53:113-114. doi: 10.1016/j.drugpo.2017.12.015. [Epub ahead of print] Caulkins JP1. Author information Abstract Cannabis legalization is often falsely depicted as a binary choice between status quo prohibition and legalizing production and distribution by (regulated) for-profit industry. There are, however, many more prudent architectures for legalization, such as restricting production and […]

[Cannabis in Parkinson’s Disease: Hype or help?]

Fortschr Neurol Psychiatr. 2018 Jan 11. doi: 10.1055/s-0043-120668. [Epub ahead of print] [Article in German; Abstract available in German from the publisher] Mainka T1, Stork J2, Hidding U1, Buhmann C1. Author information Abstract in English, German Cannabis buds and extracts as well as synthetic cannabinoids have been available on prescription to patients with severe diseases […]

Medical use of cannabis and cannabinoids containing products – Regulations in Europe and North America.

Eur J Intern Med. 2018 Jan 10. pii: S0953-6205(18)30001-3. doi: 10.1016/j.ejim.2018.01.001. [Epub ahead of print] Abuhasira R1, Shbiro L2, Landschaft Y3. Author information Abstract In 1937, the United States of America criminalized the use of cannabis and as a result its use decreased rapidly. In recent decades, there is a growing interest in the wide […]

History of marijuana use does not affect outcomes on the liver transplant waitlist.

Transplantation. 2018 Jan 10. doi: 10.1097/TP.0000000000002045. [Epub ahead of print] Kotwani P1, Saxena V1, Dodge JL2, Roberts J2, Yao F1, Hameed B1. Author information Abstract BACKGROUND: Data are limited on marijuana use and its impact on liver transplant (LT) waitlist outcomes. We aimed to assess the risk of waitlist mortality/delisting and likelihood of LT among […]

Betacaryophyllene – A phytocannabinoid as potential therapeutic modality for human sepsis?

Med Hypotheses. 2018 Jan;110:68-70. doi: 10.1016/j.mehy.2017.10.025. Epub 2017 Nov 4. Meza A1, Lehmann C2. Author information Abstract Sepsis is a clinical condition resulting from a dysregulated immune response to an infection that leads to organ dysfunction. Despite numerous efforts to optimize treatment, sepsis remains to be the main cause of death in most intensive care […]

Peripheral modulation of the endocannabinoid system in metabolic disease.

Drug Discov Today. 2018 Jan 10. pii: S1359-6446(17)30415-4. doi: 10.1016/j.drudis.2018.01.029. [Epub ahead of print] Shrestha N1, Cuffe JSM1, Hutchinson DS2, Headrick JP1, Perkins AV1, McAinch AJ3, Hryciw DH4. Author information Abstract Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoid receptor 1 (CB1) is abundantly expressed in the brain but also […]

Prospects for the Use of Cannabinoid Receptor Ligands for the Treatment of Metabolic Syndrome and Atherosclerosis: Analysis of Experimental and Clinical Data.

Vestn Ross Akad Med Nauk. 2017;72(1):59-65. doi: 10.15690/vramn779. Maslov LN, Karpov RS. Abstract An antagonist of central cannabinoid CB1 receptors rimonabant causes weight loss in patients with obesity and metabolic syndrome, improves blood lipid parameters, increases the adiponectin level, decreases the rate of glucose and glycosylated hemoglobin in patients with diabetes mellitus type-2. However, rimonabant […]

The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report.

Eur J Intern Med. 2018 Jan 8. pii: S0953-6205(18)30003-7. doi: 10.1016/j.ejim.2018.01.003. [Epub ahead of print] Abrams DI1. Author information Abstract The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a […]

The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite.

Mol Aspects Med. 2018 Jan 8. pii: S0098-2997(17)30142-5. doi: 10.1016/j.mam.2018.01.002. [Epub ahead of print] Witkamp RF1. Author information Abstract Intake, absorption and synthesis of fatty acids, including those produced by the intestinal microbiota are tightly monitored via specific receptors and, indirectly through their conversion into a variety of signalling molecules. The resulting information is integrated […]