Archive | March, 2015

Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla.

2015 Mar 31. pii: S0028-3908(15)00113-6. doi: 10.1016/j.neuropharm.2015.03.021. [Epub ahead of print] Hofer SC1, Ralvenius WT2, Gachet MS1, Fritschy JM2, Zeilhofer HU3, Gertsch J4. Author information Abstract The endocannabinoid system (ECS) comprises the cannabinoid receptors CB1 and CB2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. Recently, a novel class of negative allosteric CB1 receptor peptide […]


Need for a comprehensive national survey of cannabis use.

 2015 Mar 30;350:h1668. doi: 10.1136/bmj.h1668. Hamilton I1. Author information   Comment on High potency cannabis: a risk factor for dependence, poor psychosocial outcomes, and psychosis. [BMJ. 2015] PMID:  25825416 [PubMed – indexed for MEDLINE] Publication Types, MeSH Terms, Substances Publication Types Comment Letter MeSH Terms Cannabidiol* Cannabis/chemistry* Dronabinol* Humans Marijuana Abuse/epidemiology* Psychoses, Substance-Induced/epidemiology* Schizophrenia/epidemiology* Schizophrenic Psychology* Substances […]


Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria.

2015 Mar 29. [Epub ahead of print] Singh N1, Hroudová J, Fišar Z. Author information Abstract The aim of this study was to investigate changes in the activity of individual mitochondrial respiratory chain complexes (I, II/III, IV) and citrate synthase induced by pharmacologically different cannabinoids. In vitro effects of selected cannabinoids on mitochondrial enzymes were measured in crude mitochondrial fraction […]


Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders.

2015 Mar 29. [Epub ahead of print] Espejo-Porras F1, Piscitelli F, Verde R, Ramos JA, Di Marzo V, de Lago E, Fernández-Ruiz J. Author information Abstract Because of their neuroprotective properties, cannabinoids are being investigated in neurodegenerative disorders, mainly in preclinical studies. These disorders also include amyotrophic lateral sclerosis (ALS), a degenerative disease produced by the damage of the upper and lower motor […]


2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons.

2015 Mar 28. [Epub ahead of print] Llorente-Berzal A1, Terzian AL, di Marzo V, Micale V, Viveros MP, Wotjak CT. Author information Abstract RATIONALE: The contribution of two major endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), in the regulation of fear expression is still unknown. OBJECTIVES: We analyzed the role of different players of the endocannabinoid system on the expression of a […]


Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.

2015 Mar 28;10(1):38. [Epub ahead of print] Sirrs S1, van Karnebeek CD2,3,4,5, Peng X6, Shyr C7,8,9, Tarailo-Graovac M10,11,12, Mandal R13, Testa D14, Dubin D15, Carbonetti G16, Glynn SE17, Sayson B18,19, Robinson WP20, Han B21, Wishart D22, Ross CJ23,24,25, Wasserman WW26,27,28, Hurwitz TA29, Sinclair G30,31, Kaczocha M32,33. Author information Abstract BACKGROUND: Fatty acid amide hydrolase 2 (FAAH2) is a hydrolase that mediates the degradation of endocannabinoids in man. Alterations in the endocannabinoid system are associated with a wide […]


Interaction of cannabinoid receptor 2 and social environment modulates chronic alcohol consumption.

2015 Mar 28. pii: S0166-4328(15)00216-8. doi: 10.1016/j.bbr.2015.03.051. [Epub ahead of print] Pradier B1, Erxlebe E1, Markert A1, Rácz I2. Author information Abstract Genetic and environmental factors contribute nearly with equal power to the development of alcoholism. Environmental factors, like negative life events or emotionally disruptive conditions initiate and promote alcohol drinking and relapse. The endocannabinoid system is involved […]


Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context.

2015 Mar 27;9:98. doi: 10.3389/fncel.2015.00098. eCollection 2015. Rivera P1, Bindila L2, Pastor A3, Pérez-Martín M4, Pavón FJ1, Serrano A1, de la Torre R5, Lutz B2, Rodríguez de Fonseca F1, Suárez J1. Author information Abstract Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was […]


Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation.

2015 Mar 27;16(4):7057-7076. Patsenker E1, Sachse P2, Chicca A3, Gachet MS4, Schneider V5, Mattsson J6, Lanz C7, Worni M8, de Gottardi A9, Semmo M10, Hampe J11, Schafmayer C12, Brenneisen R13, Gertsch J14, Stickel F15, Semmo N16,17. Author information Abstract The endocannabinoid (EC) system is implicated in many chronic liver diseases, including hepatitis C viral (HCV) infection. Cannabis consumption is associated with fibrosis progression in patients with chronic hepatitis C (CHC), […]