Archive | September, 2015

Cannabinoids, cannabinoid receptors and tinnitus.

 2015 Sep 30. pii: S0378-5955(15)30036-8. doi: 10.1016/j.heares.2015.09.014. [Epub ahead of print] Smith PF1, Zheng Y2. Author information Abstract One hypothesis suggests that tinnitus is a form of sensory epilepsy, arising partly from neuronal hyperactivity in auditory regions of the brain such as the cochlear nucleus and inferior colliculus. Although there is currently no effective drug treatment […]

Examining the locations of medical marijuana dispensaries in Los Angeles.

2015 Sep 30. doi: 10.1111/dar.12325. [Epub ahead of print] Thomas C1, Freisthler B1. Author information Abstract INTRODUCTION AND AIMS: Little is known about the spatial distribution of medical marijuana dispensaries, particularly whether or not sites are disproportionately located in minority or communities with younger populations. This paper will assess if there is a relationship between medical marijuana dispensaries and neighbourhood […]

Cannabis – the Israeli perspective.

2015 Sep 30. pii: /j/jbcpp.ahead-of-print/jbcpp-2015-0091/jbcpp-2015-0091.xml. doi: 10.1515/jbcpp-2015-0091. [Epub ahead of print] Mechoulam R. Abstract Short overviews are presented on the historical uses of cannabis in the Middle East and on the more recent scientific and medical research on phytocannabinoids and the endocannabinoid system, with emphasis on research contributions from Israel. These are followed by examples […]

Targeting the endocannabinoid system to treat anxiety-related disorders.

2015 Sep 30. pii: /j/jbcpp.ahead-of-print/jbcpp-2015-0058/jbcpp-2015-0058.xml. doi: 10.1515/jbcpp-2015-0058. [Epub ahead of print] Korem N, Zer-Aviv TM, Ganon-Elazar E, Abush H, Akirav I. Abstract The endocannabinoid system plays an important role in the control of emotions, and its dysregulation has been implicated in several psychiatric disorders. The most common self-reported reason for using cannabis is rooted in its ability to reduce […]

Developmental regulation of fear learning and anxiety behavior by endocannabinoids.

 2015 Sep 30. doi: 10.1111/gbb.12253. [Epub ahead of print] Lee TT1, Hill MN2, Lee FS3,4,5. Author information Abstract The developing brain undergoes substantial maturation into adulthood and the development of specific neural structures occurs on differing timelines. Transient imbalances between developmental trajectories of corticolimbic structures, which are known to contribute to regulation over fear learning and anxiety, […]

Variability in medical marijuana laws in the United States.

 2015 Sep;29(3):639-642. Bestrashniy J1, Winters KC2. Author information Abstract Marijuana use and its distribution raise several complex health, social, and legal issues in the United States. Marijuana is prohibited in only 23 states and promarijuana laws are likely to be introduced in these states in the future. Increased access to and legalization of medical marijuana may have an impact on recreational marijuana use […]

The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review.

 2015;231:95-128. Fowler CJ1. Author information Abstract The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g. cyclooxygenase-2, COX-2). In the present article, the in vivo data for compounds inhibiting endocannabinoid metabolism have been reviewed, focussing on inflammation and pain. Potential reasons for […]

Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.

2015 Sep 29;9:379. doi: 10.3389/fncel.2015.00379. eCollection 2015. Rivera P1, Blanco E2, Bindila L3, Alen F1, Vargas A1, Rubio L4, Pavón FJ1, Serrano A1, Lutz B3, Rodríguez de Fonseca F1, Suárez J1. Author information Abstract Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective […]

The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease.

 2015 Oct;26(10):524-37. doi: 10.1016/j.tem.2015.07.007. Mazier W1, Saucisse N1, Gatta-Cherifi B2, Cota D3. Author information Abstract The endocannabinoid system (ECS) functions to adjust behavior and metabolism according to environmental changes in food availability. Its actions range from the regulation of sensory responses to the development of preference for the consumption of calorically-rich food and control of its metabolic handling. […]

TRPV1 Channel: A Potential Drug Target for Treating Epilepsy.

2015;13(2):239-47. Nazıroglu M1. Author information Abstract Epilepsy has 2-3% incidence worldwide. However, present antiepileptic drugs provide only partial control of seizures. Calcium ion accumulation in hippocampal neurons has long been known as a major contributor to the etiology of epilepsy. TRPV1 is a calcium-permeable channel and mediator of epilepsy in the hippocampus. TRPV1 is expressed […]