Archive | May, 2016

Phytochemicals as adjunctive with conventional anticancer therapies.

 2016 May 31. [Epub ahead of print] de Julián-Ortiz JV, Gozalbes R, Besalú E1, Farzaei MH, Bahramsoltani R, Rahimi R2. Author information Abstract BACKGROUND: Cancer is defined as the abnormal proliferations of cells which could occur in any tissue and can cause life-threatening malignancies with high financial costs for both patients and health care system. Plant-derived secondary metabolites are shown […]

Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation.

2016 May 26. pii: S0896-6273(16)30157-X. doi: 10.1016/j.neuron.2016.04.043. [Epub ahead of print] Gremel CM1, Chancey JH2, Atwood BK2, Luo G2, Neve R3, Ramakrishnan C4, Deisseroth K4, Lovinger DM5, Costa RM6. Author information Abstract Everyday function demands efficient and flexible decision-making that allows for habitual and goal-directed action control. An inability to shift has been implicated in disorders with impaired decision-making, including obsessive-compulsive disorder and […]

Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model.

2016 May 31. pii: S0889-1591(16)30147-7. doi: 10.1016/j.bbi.2016.05.020. [Epub ahead of print] Tao Y1, Li L2, Jiang B1, Feng Z1, Yang L1, Tang J1, Chen Q1, Zhang J1, Tan Q1, Feng H1, Chen Z3, Zhu G4. Author information Abstract Excessive inflammatory responses are involved in secondary brain injury during germinal matrix hemorrhage (GMH). The process of microglial polarization to the pro-inflammatory M1 or anti-inflammatory M2 phenotypes is […]

CB2 Cannabinoid Receptor As Potential Target against Alzheimer’s Disease.

2016 May 31;10:243. doi: 10.3389/fnins.2016.00243. eCollection 2016. Aso E1, Ferrer I1. Author information Abstract The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules and receptors involved in the homeostatic control of several physiological functions. Accumulated evidence suggests a role for CB2 receptors in Alzheimer’s disease (AD) and indicates […]

Endocannabinoid system: a promising therapeutic target for the treatment of haematological malignancies?

 2016 May 30. [Epub ahead of print] Giaginis C1, Lakiotaki E, Korkolopoulou P, Konstantopoulos K, Patsouris E, Theocharis S. Author information Abstract BACKGROUND: The therapeutic properties of cannabinoids are well-known since ancient years. Growing evidence exist on endocannabinoid system (ECS) modulation related with human tumorigenesis. OBJECTIVE: Taking into account the substantial role of ECS on immune cell regulation, the present review is […]

β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes.

2016 May 28. doi: 10.1002/mnfr.201600197. [Epub ahead of print] Kamikubo R1, Kai K1, Tsuji-Naito K2, Akagawa M1. Author information Abstract SCOPE: Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide, characterized by excessive hepatic lipid accumulation without significant ethanol consumption. We have performed a screening for medicinal foods that inhibit hepatocytic lipid accumulation […]

Could cannabidiol be used as an alternative to antipsychotics?

2016 May 28;80:14-21. doi: 10.1016/j.jpsychires.2016.05.013. [Epub ahead of print] Fakhoury M1. Author information Abstract Schizophrenia is a mental disorder that affects close to 1% of the population. Individuals with this disorder often present signs such as hallucination, anxiety, reduced attention, and social withdrawal. Although antipsychotic drugs remain the cornerstone of schizophrenia treatment, they are associated […]

The involvement of TRPV1 in emesis and anti-emesis.

2015 May 21;2(2):258-76. doi: 10.1080/23328940.2015.1043042. Rudd JA1, Nalivaiko E2, Matsuki N3, Wan C4, Andrews PL5. Author information Abstract Diverse transmitter systems (e.g. acetylcholine, dopamine, endocannabinoids, endorphins, glutamate, histamine, 5-hydroxytryptamine, substance P) have been implicated in the pathways by which nausea and vomiting are induced and are targets for anti-emetic drugs (e.g. 5-hydroxytryptamine3 and tachykinin NK1 antagonists). The involvement of TRPV1 […]

TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer.

 2016 May 27. doi: 10.18632/oncotarget.9663. [Epub ahead of print] Elbaz M1,2,3, Ahirwar D1,2, Xiaoli Z4, Zhou X5, Lustberg M6, Nasser MW1,2, Shilo K1,2, Ganju RK1,2. Author information Abstract Transient receptor potential vanilloid type-2 (TRPV2) is an ion channel that is triggered by agonists like cannabidiol (CBD). Triple negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Chemotherapy is still the first […]

Investigational drugs for treating agitation in persons with dementia.

 2016 May 27. [Epub ahead of print] Garay RP1, Citrome L2, Grossberg GT3, Cavero I4, Llorca PM5. Author information Abstract INTRODUCTION: Agitation is common and distressing in persons with dementia, but safe, effective treatments remain elusive. In this review, the authors describe investigational compounds in ongoing or recently completed clinical trials for this indication and provide an opinion on […]