Archive | October, 2016

Effect of marijuana use on thyroid function and autoimmunity.

2016 Oct 31. [Epub ahead of print] Malhotra S1, Heptulla RA2,3, Homel P4,5, Motaghedi R6,7. Author information Abstract BACKGROUND: Marijuana is legalized for medical use in 24 states and for recreational use in five. However, effects of marijuana use on thyroid function and autoimmunity are unknown. Objective and hypotheses: We performed a cross-sectional analysis of data from the National Health and Nutrition Examination […]

Pros and cons of medical cannabis use by people with chronic brain disorders.

2016 Oct 31. [Epub ahead of print] Suryadevara U, Bruijnzeel DM, Nuthi M, Jagnarine DA, Tandon R, Bruijnzeel AW1. Author information Abstract BACKGROUND: Cannabis is the most widely used illicit drug in the world and there is growing concern about the mental health effects of cannabis use. These concerns are at least partly due to the strong increase in recreational and medical cannabis use and […]

Medical cannabis use in Canada: vapourization and modes of delivery.

2016 Oct 29;13(1):30. Shiplo S1, Asbridge M2, Leatherdale ST1, Hammond D3. Author information Abstract BACKGROUND: The mode of medical cannabis delivery-whether cannabis is smoked, vapourized, or consumed orally-may have important implications for its therapeutic efficacy and health risks. However, there is very little evidence on current patterns of use among Canadian medical cannabis users, particularly with respect to modes of delivery. The current study […]

National and Northern New England Opioid Prescribing Patterns, 2013-2014.

2016 Oct 29. pii: pnw231. [Epub ahead of print] Toth AR1, Possidente CJ2, Sawyer LM3, DiParlo MA4, Fanciullo GJ5. Author information Abstract OBJECTIVE : To evaluate current opioid prescribing patterns nationally and regionally across several northern New England states and compare with prescription data on an institutional level over a two-year period, between 2013 and 2014. DESIGN, SETTING, AND SUBJECTS: […]

Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia.

Neurosci Lett. 2016 Oct 28;633:87-93. doi: 10.1016/j.neulet.2016.09.020. Epub 2016 Sep 14. Szűcs E1, Dvorácskó S1, Tömböly C1, Büki A2, Kékesi G2, Horváth G2, Benyhe S3. Author information Abstract Schizophrenia is a serious mental health disorder characterized by several behavioral and biochemicel abnormalities. In a previous study we have shown that mu-opioid (MOP) receptor signaling is impaired in specific brain regions of our three-hit animal […]

Dietary olive oil induces cannabinoid CB2 receptor expression in adipose tissue of ApcMin/+ transgenic mice.

Nutr Healthy Aging. 2016 Oct 27;4(1):73-80. doi: 10.3233/NHA-160008. Notarnicola M1, Tutino V1, Tafaro A2, Bianco G2, Guglielmi E1, Caruso MG1. Author information Abstract BACKGROUND: Cannabinoid- 2 (CB2) receptor is known for its anti-obesity effects silencing the activated immune cells that are key drivers of metabolic syndrome and inflammation. Nutritional interventions in experimental models of carcinogenesis have been demonstrated to modulate tissue inflammation […]

Role of cannabis in digestive disorders.

2016 Oct 27. [Epub ahead of print] Goyal H1, Singla U, Gupta U, May E. Author information Abstract Cannabis sativa, a subspecies of the Cannabis plant, contains aromatic hydrocarbon compounds called cannabinoids. [INCREMENT]-Tetrahydrocannabinol is the most abundant cannabinoid and is the main psychotropic constituent. Cannabinoids activate two types of G-protein-coupled cannabinoid receptors: cannabinoid type 1 receptor and cannabinoid type 2 receptor. There has been ongoing interest and development in […]

Marijuana practices and patterns of use among young adult medical marijuana patients and non-patient marijuana users.

Drug Alcohol Depend. 2016 Oct 26;170:181-188. doi: 10.1016/j.drugalcdep.2016.10.025. [Epub ahead of print] Lankenau SE1, Fedorova EV2, Reed M3, Schrager SM4, Iverson E5, Wong CF6. Author information Abstract BACKGROUND: Little is known about young adult medical marijuana patients (MMP) and their marijuana using patterns and practices, which includes frequency of use, sourcing of marijuana products, forms/modes of administration, and patterns of illicit/prescription drug misuse, compared to non-patient marijuana users (NPU). […]

Loss of Cannabinoid CB 1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.

Cereb Cortex. 2016 Oct 5:1-15. doi: 10.1093/cercor/bhw309. [Epub ahead of print]Díaz-Alonso J1,2,3, de Salas-Quiroga A1,2, Paraíso-Luna J1,2, García-Rincón D1,2, Garcez PP4,5, Parsons M6, Andradas C1,7, Sánchez C1,7, Guillemot F8, Guzmán M1,2, Galve-Roperh I1,2. Author information Abstract Neuronal migration is a fundamental process of brain development, and its disruption underlies devastating neurodevelopmental disorders. The transcriptional programs governing this process are relatively well characterized. However, how environmental cues […]

Oxyradical Stress Increases the Biosynthesis of 2-Arachidonoylglycerol: Involvement of NADPH Oxidase.

2016 Oct 26:ajpcell.00251.2015. doi: 10.1152/ajpcell.00251.2015. [Epub ahead of print] Matthews AT1, Lee JH1, Borazjani A1, Mangum LC1, Hou X1, Ross MK2. Author information Abstract NADPH oxidase (Nox)-derived oxyradicals contribute to atherosclerosis by oxidizing low-density lipoproteins (LDL), leading to their phagocytosis by vascular macrophages. Endocanna-binoids, such as 2-arachidonoylglycerol (2-AG), might be an important link between oxidative stress and atherosclerosis. We hypothesized […]