Archive | January, 2017

Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype.

Biochem Pharmacol. 2017 Jan 31. pii: S0006-2952(17)30044-8. doi: 10.1016/j.bcp.2017.01.014. [Epub ahead of print] Hillger JM1, le Roy B1, Wang Z2, Mulder-Krieger T1, Boomsma DI3, Slagboom PE4, Danen EH2, IJzerman AP1, Heitman LH5. Author information Abstract The Cannabinoid Receptor 2 (CB2R) is a G protein-coupled receptor (GPCR) investigated intensively as therapeutic target, however no drug has reached the market yet. We investigated personal differences in […]

Serum endocannabinoids and N-acyl ethanolamines and the influence of simulated solar UVR exposure in humans in vivo.

Photochem Photobiol Sci. 2017 Jan 31. doi: 10.1039/c6pp00337k. [Epub ahead of print] Felton SJ1, Kendall AC2, Almaedani AF2, Urquhart P2, Webb AR3, Kift R3, Vail A4, Nicolaou A2, Rhodes LE1. Author information Abstract Solar ultraviolet radiation (UVR) exposure of human skin has beneficial and harmful effects on health, including impact on immune function, inflammation and reportedly mood, but these are not fully elucidated. Since […]

Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain.

Scand J Pain. 2017 Jan;14:25-38. doi: 10.1016/j.sjpain.2016.09.011. Epub 2016 Nov 1. González-Rodríguez S1, Poras H2, Menéndez L1, Lastra A1, Ouimet T2, Fournié-Zaluski MC2, Roques BP3, Baamonde A1. Author information Abstract BACKGROUND: The first line pharmacological treatment of cancer pain is morphine and surrogates but a significant pain relief and a reduction of the side-effects of […]

Song-associated reward correlates with endocannabinoid-related gene expression in male European starlings (Sturnus vulgaris).

Neuroscience. 2017 Jan 29. pii: S0306-4522(17)30041-6. doi: 10.1016/j.neuroscience.2017.01.028. [Epub ahead of print] Hahn AH1, Merullo DP2, Spool JA2, Angyal CS2, Stevenson SA2, Riters LV2. Author information Abstract Vocal communication is required for successful social interactions in numerous species. During the breeding season, songbirds produce songs that are reinforced by behavioral consequences (e.g., copulation). However, some songbirds also produce songs not obviously […]

Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome.

Gynecol Endocrinol. 2017 Jan 28:1-5. doi: 10.1080/09513590.2016.1269742. [Epub ahead of print] Cui N1, Yang Y1, Xu Y1, Zhang J1, Jiang L1, Hao G1. Author information Abstract This study aimed to investigate the correlation between endocannabinoids and polycystic ovary syndrome (PCOS), and the expression levels of endocannabinoids in different phases of menstruation. The expression of cannabinoid receptors (CB1) and fatty acid amide […]

Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism.

Sci Rep. 2017 Jan 27;7:41362. doi: 10.1038/srep41362. Medeiros D1,2, Silva-Gonçalves LD1, da Silva AM1, Dos Santos Cabrera MP3, Arcisio-Miranda M1. Author information Abstract Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism […]

Alternate policing strategies: Cost-effectiveness of cautioning for cannabis offences.

Int J Drug Policy. 2017 Jan 27. pii: S0955-3959(16)30383-8. doi: 10.1016/j.drugpo.2016.12.012 [Epub ahead of print] Shanahan M1, Hughes CE2, McSweeney T3, Griffin BA4. Author information Abstract BACKGROUND: There is increasing international interest in alternatives to the use of arrest for minor drug offences. While Australia has been at the forefront in the provision of diversionary programs for minor drug offences there remain key gaps in […]

Activation of Both CB1 and CB2 Endocannabinoid Receptors Is Critical for Masculinization of the Developing Medial Amygdala and Juvenile Social Play Behavior.

eNeuro. 2017 Jan 27;4(1). pii: ENEURO.0344-16.2017. doi: 10.1523/ENEURO.0344-16.2017. Argue KJ1, VanRyzin JW1, Falvo DJ1, Whitaker AR1, Yu SJ1, McCarthy MM1. Author information Abstract Juvenile social play behavior is a shared trait across a wide variety of mammalian species. When play is characterized by the frequency or duration of physical contact, males usually display more play relative to females. The endocannabinoid system contributes to the […]

The endocannabinoid system: no longer anonymous in the control of nitrergic signalling?

J Mol Cell Biol. 2017 Jan 27. pii: mjx008. doi: 10.1093/jmcb/mjx008. [Epub ahead of print] Lipina C1, Hundal HS2. Author information Abstract The endocannabinoid system (ECS) is a key cellular signalling system that has been implicated in the regulation of diverse cellular functions. Importantly, growing evidence suggests that the biological actions of the ECS may, in part, […]

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus.

Mol Metab. 2017 Jan 27;6(4):374-381. doi: 10.1016/j.molmet.2017.01.004. eCollection 2017. Morozov YM1, Koch M2, Rakic P1, Horvath TL3. Author information Abstract OBJECTIVES: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R). However, the underlying mechanisms are not fully understood. Generally, cannabinoid-conducted […]