Archive | October, 2017

Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice.

J Reward Defic Syndr Addict Sci. 2017;3(2):21-27. Epub 2017 Oct 31. Figueiredo A1, Hamilton J1, Marion M1, Blum K2, Kaczocha M3, Haj-Dahmane S1, Deutsch D4, Thanos PK1. Author information Abstract The endocannabinoid (eCB) system is involved in a wide range of behavioral disorders including alcoholism. Inhibition of fatty acid amide hydrolase (FAAH), the principal enzyme […]

Remote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors.

Cell Physiol Biochem. 2017 Oct 31;43(6):2516-2524. doi: 10.1159/000484460. [Epub ahead of print] Jing N, Fang B, Wang ZL, Ma H. Abstract BACKGROUND/AIMS: Remote ischemic preconditioning (RIPC) has protective effects on spinal cord ischemia reperfusion (I/R) injury, but the potential mechanisms remain unclear. In our study, the effects and underlying mechanisms of RIPC on blood-spinal cord […]

Regulating Hemp and Cannabis-Based Products.

NCSL Legisbrief. 2017 Oct;25(37):1-2. Bridges M1, Hanson K1. Author information Abstract (1)Different state agencies often regulate the hemp and cannabis industries separately. (2) Pharmaceutical products derived from cannabis are currently in clinical trials for approval in the U.S. and other countries. One product is already approved for use in 29 countries, but not in the […]

The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: clues for other neuroinflammatory diseases.

Prog Neurobiol. 2017 Oct 30. pii: S0301-0082(17)30070-9. doi: 10.1016/j.pneurobio.2017.10.007. [Epub ahead of print] Chiurchiù V1, van der Stelt M2, Centonze D3, Maccarrone M4. Author information Abstract Multiple sclerosis is the most common inflammatory demyelinating disease of the central nervous system, caused by an autoimmune response against myelin that eventually leads to progressive neurodegeneration and disability. […]

Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization.

Brain Behav Immun. 2017 Oct 24. pii: S0889-1591(17)30477-4. doi: 10.1016/j.bbi.2017.10.021. [Epub ahead of print] Braun M1, Khan ZT2, Khan MB3, Kumar M4, Ward A1, Achyut BR5, Arbab AS5, Hess DC3, Hoda MN6, Baban B7, Dhandapani KM1, Vaibhav K8. Author information Abstract Inflammation is an important mediator of secondary neurological injury after traumatic brain injury (TBI). […]

The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice.

Int J Mol Sci. 2017 Oct 28;18(11). pii: E2268. doi: 10.3390/ijms18112268. McDonnell C1,2, Leánez S3,4, Pol O5,6. Author information Abstract The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 […]

A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders.

Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):301-312. doi: 10.9758/cpn.2017.15.4.301. Lim K1, See YM1, Lee J1,2. Author information Abstract The discovery of endocannabinoid’s role within the central nervous system and its potential therapeutic benefits have brought forth rising interest in the use of cannabis for medical purposes. The present review aimed to synthesize and evaluate the available […]

Marijuana Use and Organ Transplantation: a Review and Implications for Clinical Practice.

Curr Psychiatry Rep. 2017 Oct 27;19(11):91. doi: 10.1007/s11920-017-0843-1. Rai HS1, Winder GS2. Author information Abstract PURPOSE OF REVIEW: Physicians of all disciplines must rapidly adjust their clinical practices following the expansion of marijuana legalization across the country. Organ transplantation teams are uniquely struggling in this gray zone with eight states having passed laws explicitly banning […]

Anti-migraine effect of ∆9-tetrahydrocannabinol in the female rat.

Eur J Pharmacol. 2017 Oct 27. pii: S0014-2999(17)30723-9. doi: 10.1016/j.ejphar.2017.10.054. [Epub ahead of print] Kandasamy R1, Dawson CT2, Craft RM3, Morgan MM4. Author information Abstract Current anti-migraine treatments have limited efficacy and many side effects. Although anecdotal evidence suggests that marijuana is useful for migraine, this hypothesis has not been tested in a controlled experiment. […]

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.

Front Cell Neurosci. 2017 Oct 27;11:338. doi: 10.3389/fncel.2017.00338. eCollection 2017. Sheth S1, Mukherjea D2, Rybak LP1,2, Ramkumar V1. Author information Abstract Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has […]