Archive | January, 2018

Contemporary Routes of Cannabis Consumption: A Primer for Clinicians.

J Am Osteopath Assoc. 2018 Feb 1;118(2):67-70. doi: 10.7556/jaoa.2018.020. Peters J, Chien J. Abstract Although cannabis use is federally prohibited, medical cannabis is legal in some form in 30 states and the District of Columbia, and recreational use is legal in 8 states and the District of Columbia. The increasing legal acceptance of cannabis has […]

Examining effects of medical cannabis narratives on beliefs, attitudes, and intentions related to recreational cannabis: A web-based randomized experiment.

Drug Alcohol Depend. 2018 Jan 31;185:219-225. doi: 10.1016/j.drugalcdep.2017.11.028. [Epub ahead of print] Sznitman SR1, Lewis N2. Author information Abstract BACKGROUND: This experimental study tests effects of exposure to video narratives about successful symptom relief with Medical Cannabis (MC) on attitudes, beliefs, and intentions related to recreational cannabis use. METHODS: Patient video testimonials were modeled after […]

The Canadian Cannabis Act legalizes and regulates recreational cannabis use in 2018.

Health Policy. 2018 Jan 31. pii: S0168-8510(18)30023-X. doi: 10.1016/j.healthpol.2018.01.009. [Epub ahead of print] Cox C1. Author information Abstract Canada is on the cusp of an unprecedented change in its governmental approach to recreational cannabis consumption. By July of 2018 the country will legalize and regulate recreational cannabis use across the country via the implementation of the […]

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications.

Front Aging Neurosci. 2018 Jan 30;10:04. doi: 10.3389/fnagi.2018.00004. eCollection 2018. Uddin MS1, Stachowiak A2, Mamun AA1, Tzvetkov NT3, Takeda S4, Atanasov AG5,6, Bergantin LB7, Abdel-Daim MM8,9, Stankiewicz AM5. Author information Abstract Alzheimer’s disease (AD) is the most common cause of progressive dementia in the elderly. It is characterized by a progressive and irreversible loss of […]

Medical cannabis: A forward vision for the clinician.

Eur J Pain. 2018 Jan 29. doi: 10.1002/ejp.1185. [Epub ahead of print] Fitzcharles MA1,2, Eisenberg E3,4. Author information Abstract Medical cannabis has entered mainstream medicine and is here to stay. Propelled by public advocacy, the media and mostly anecdote rather than sound scientific study, patients worldwide are exploring marijuana use for a vast array of […]

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.

Front Immunol. 2018 Jan 29;9:38. doi: 10.3389/fimmu.2018.00038. eCollection 2018. Chiurchiù V1,2, Leuti A1,2, Maccarrone M1,2. Author information Abstract Inflammation is an immune response that works as a contained fire that is pre-emptively sparked as a defensive process during infections or upon any kind of tissue insult, and that is spontaneously extinguished after elimination or termination […]

Police crackdowns, structural violence and impact on the well-being of street cannabis users in a Nigerian city.

Int J Drug Policy. 2018 Jan 29;54:114-122. doi: 10.1016/j.drugpo.2018.01.012. [Epub ahead of print] Nelson EU1. Author information Abstract BACKGROUND: There is abundant literature on the impact of law enforcement on cannabis markets, but scant literature on the effects of law enforcement on cannabis users. This study undertook a qualitative exploration of police crackdowns as a […]

Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities.

Mol Neurobiol. 2018 Jan 25. doi: 10.1007/s12035-018-0898-y. [Epub ahead of print] Upadhya D1,2,3, Castro OW1,2,4, Upadhya R1,2, Shetty AK5,6. Author information Abstract The hippocampus is one of the most susceptible regions in the brain to be distraught with status epilepticus (SE) induced injury. SE can occur from numerous causes and is more frequent in children […]

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet. 2018 Jan 25. pii: S0140-6736(18)30136-3. doi: 10.1016/S0140-6736(18)30136-3. [Epub ahead of print] Thiele EA1, Marsh ED2, French JA3, Mazurkiewicz-Beldzinska M4, Benbadis SR5, Joshi C6, Lyons PD7, Taylor A8, Roberts C8, Sommerville K9; GWPCARE4 Study Group. Collaborators (34) Author information Abstract BACKGROUND: Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment […]

Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: reversal by cannabidiol.

Brain Res Bull. 2018 Jan 25. pii: S0361-9230(17)30371-4. doi: 10.1016/j.brainresbull.2018.01.014. [Epub ahead of print] da Silva VK1, de Freitas BS2, Dornelles VC2, Kist LW3, Bogo MR3, Silva MC4, Streck EL4, Hallak JE5, Zuardi AW5, Crippa JAS5, Schröder N6. Author information Abstract Evidence has demonstrated iron accumulation in specific brain regions of patients suffering from neurodegenerative […]