Archive | March, 2018

Implementation of a generic liquid chromatographic method development workflow: Application to the analysis of phytocannabinoids and Cannabis sativa extracts.

J Pharm Biomed Anal. 2018 Mar 31;155:116-124. doi: 10.1016/j.jpba.2018.03.059. [Epub ahead of print] Fekete S1, Sadat-Noorbakhsh V2, Schelling C2, Molnár I3, Guillarme D2, Rudaz S2, Veuthey JL2. Author information Highlights • A generic RPLC method development workflow was proposed. • Screening, optimization, virtual refinement and virtual robustness testing were done. • This workflow was applied […]

Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation.

Horm Mol Biol Clin Investig. 2018 Mar 30. pii: /j/hmbci.ahead-of-print/hmbci-2018-0013/hmbci-2018-0013.xml. doi: 10.1515/hmbci-2018-0013. [Epub ahead of print] Mastinu A1, Premoli M1, Ferrari-Toninelli G1, Tambaro S2, Maccarinelli G1, Memo M1, Bonini SA1. Author information Abstract The use of different natural and/or synthetic preparations of Cannabis sativa is associated with therapeutic strategies for many diseases. Indeed, thanks to […]

[The Road towards the Responsible and Safe Legalization of Cannabis Use in Portugal].

Acta Med Port. 2018 Feb 28;31(2):115-125. doi: 10.20344/amp.10093. Epub 2018 Feb 28. [Article in Portuguese; Abstract available in Portuguese from the publisher] Baptista-Leite R1, Ploeg L2. Author information Abstract in English, Portuguese INTRODUCTION: Recently, the world has seen examples of the legalization of cannabis for recreational purposes. Due to the diversity of experiences in progress, it […]

Alkylsilyl speciation and direct sample preparation of plant cannabinoids prior to their analysis by GC-MS.

Anal Chim Acta. 2018 Aug 27;1021:51-59. doi: 10.1016/j.aca.2018.03.049. Epub 2018 Mar 30. Fodor B1, Boldizsár I2, Molnár-Perl I3. Author information Abstract A literature criticism is given on methods currently using gas chromatography mass spectrometry (GC-MS) to determine plant cannabinoids (p-CBDs). In this study, trialkylsilylation of seven p-CBDs (including their transformation products formed in the drug […]

Evaluation of Bisphenol A influence on endocannabinoid system in pregnant women.

Chemosphere. 2018 Mar 30;203:387-392. doi: 10.1016/j.chemosphere.2018.03.195. [Epub ahead of print] Zbucka-Kretowska M1, Zbucki R2, Parfieniuk E3, Maslyk M4, Lazarek U5, Miltyk W5, Czerniecki J1, Wolczynski S1, Kretowski A2, Ciborowski M6. Author information Highlights • BPA may affect plasma metabolome of pregnant women. • Plasma levels of BPA and endocannabinoids are positively correlated. • BPA may […]

Profiles of Patients Who Use Marijuana for Inflammatory Bowel Disease.

Dig Dis Sci. 2018 Mar 29. doi: 10.1007/s10620-018-5040-5. [Epub ahead of print] Kerlin AM1, Long M2, Kappelman M2, Martin C2, Sandler RS2. Author information Abstract BACKGROUND: Marijuana is legal in a number of states for indications that include inflammatory bowel diseases (IBD), and patients are interested in its potential benefits. AIMS: We aimed to describe […]

The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension.

Cell Physiol Biochem. 2018 Mar 29;46(2):727-739. doi: 10.1159/000488730. [Epub ahead of print] Polak A1, Harasim-Symbor E1, Malinowska B2, Kasacka I3, Lewandowska A3, Chabowski A1. Author information Abstract BACKGROUND/AIMS: Recent interest in the use of cannabinoids as therapeutic agents has revealed the involvement of the endogenous cannabinoid system (ECS) in the regulation of the cardiovascular system […]

Medical Marijuana Update.

Workplace Health Saf. 2018 Apr;66(4):212. doi: 10.1177/2165079918758341. Phillips JA1. Author information Abstract The majority of states now allow medical marijuana, and recent court decisions could influence workplace practice concerning its use. KEYWORDS: chronic illnesses; disability case management; government regulation; job accommodation; management; medical marijuana PMID: 29587619   DOI: 10.1177/2165079918758341

A National Needs Assessment of Canadian Nurse Practitioners Regarding Cannabis for Therapeutic Purposes.

Cannabis Cannabinoid Res. 2018 Mar 1;3(1):66-73. doi: 10.1089/can.2018.0002. eCollection 2018. Balneaves LG1, Alraja A2, Ziemianski D3,4, McCuaig F5, Ware M3,6,7,8. Author information Abstract Introduction: In Canada, the Access to Cannabis for Medical Purposes Regulations (ACMPR) has given nurse practitioners (NPs) the power to authorize cannabis for therapeutic purposes (CTP) to eligible patients. This expansion in […]

Zebrafish models relevant to studying central opioid and endocannabinoid systems.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 28. pii: S0278-5846(18)30054-X. doi: 10.1016/j.pnpbp.2018.03.024. [Epub ahead of print] Demin KA1, Meshalkina DA1, Kysil EV2, Antonova KA2, Volgin AD3, Yakovlev OA3, Alekseeva PA4, Firuleva MM2, Lakstygal AM2, de Abreu MS5, Barcellos LJG6, Bao W7, Friend AJ8, Amstislavskaya TG9, Rosemberg DB10, Musienko PE11, Song C12, Kalueff AV13. Author information Abstract […]