Archive | April, 2018

Cannabis, from Plant to Pill.

Br J Clin Pharmacol. 2018 Apr 27. doi: 10.1111/bcp.13618. [Epub ahead of print] Grof CPL1,2. Author information Abstract The therapeutic application of Cannabis is attracting substantial public and clinical interest. The Cannabis plant has been described as a veritable ‘treasure trove’, producing more than a hundred different cannabinoids, although the focus to date has been […]

The role of cannabinoid signaling in acute and chronic kidney diseases.

Kidney Int. 2018 Apr 26. pii: S0085-2538(18)30140-6. doi: 10.1016/j.kint.2018.01.024. [Epub ahead of print] Barutta F1, Bruno G1, Mastrocola R2, Bellini S1, Gruden G3. Author information Abstract The endogenous cannabinoids anandamide and 2-arachidonoylglycerol bind to the cannabinoid receptors of type 1 and 2. These receptors are also the binding sites for exogenous, both natural and synthetic, […]

Review of the neurological benefits of phytocannabinoids.

Surg Neurol Int. 2018 Apr 26;9:91. doi: 10.4103/sni.sni_45_18. eCollection 2018. Maroon J1, Bost J1. Author information Abstract BACKGROUND: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia. The phytocannabinoids, cannabidiol (CBD), and delta-9-tetrahydrocannabinol (Δ9-THC) are the most studied extracts from cannabis […]

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.

Transl Psychiatry. 2018 Apr 26;8(1):92. doi: 10.1038/s41398-018-0141-7. Bedse G1, Bluett RJ2,3, Patrick TA2, Romness NK2, Gaulden AD2, Kingsley PJ4, Plath N5, Marnett LJ4, Patel S2,3,6. Author information Abstract Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety of preclinical models. Pharmacological inhibition of endocannabinoid-degrading enzymes, such as fatty acid […]

Possible role of hippocampal GPR55 in spatial learning and memory in rats.

Acta Neurobiol Exp (Wars). 2018;78(1):41-50. Marichal-Cancino BA1, Fajardo-Valdez A2, Ruiz-Contreras AE3, Méndez-Díaz M2, Prospéro-García O2. Author information Abstract Endocannabinoids (eCBs) are involved in the hippocampal mechanisms of spatial learning and memory in rats. Although eCBs exert many of their actions on spatial learning and memory via CB1 receptors, the putative cannabinoid receptor GPR55 (expressed in […]

Cannabinoid receptor 2: a potential novel therapeutic target for sepsis?

Acta Clin Belg. 2018 Apr 25:1-5. doi: 10.1080/17843286.2018.1461754. [Epub ahead of print] He Q1, Xiao F2, Yuan Q1, Zhang J1, Zhan J1, Zhang Z1. Author information Abstract OBJECTIVE: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is the most common cause of death among critically ill patients in non-coronary […]

Genetic Variant Q63R of Cannabinoid Receptor 2 (CB2R) Causes Differential ERK Phosphorylation in Human Immune Cells.

Genet Test Mol Biomarkers. 2018 Apr 25. doi: 10.1089/gtmb.2018.0005. [Epub ahead of print] Wang J1, Xu J1, Liu J1, Zhu H1, Peng Y1, Ding ZM1, Hua H1. Author information Abstract BACKGROUND: The cannabinoid receptor 2 (CB2R) is primarily expressed in immune tissues and implicated in immune regulation. In models of inflammatory diseases, modulation of CB2R […]

β-Caryophyllene (BCP) ameliorates MPP+ induced cytotoxicity.

Biomed Pharmacother. 2018 Apr 25;103:1086-1091. doi: 10.1016/j.biopha.2018.03.168. [Epub ahead of print] Wang G1, Ma W1, Du J2. Author information Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases resulting from the continuous death of dopaminergic neurons in substantia nigra. MPP+ (1-methyl-4-phenylpyridinium) has been reported to be a major neurotoxin causing neurotoxic insults […]

Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids.

Front Oncol. 2018 Apr 24;8:114. doi: 10.3389/fonc.2018.00114. eCollection 2018. Yasmin-Karim S1,2,3, Moreau M2,3,4, Mueller R1,2,5, Sinha N1,2, Dabney R6, Herman A6, Ngwa W1,2,3,4. Author information Abstract Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could […]

Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids

ORIGINAL RESEARCH ARTICLE Sayeda Yasmin-Karim1,2,3, Michele Moreau2,3,4, Romy Mueller1,2,5, Neeharika Sinha1,2, Raymond Dabney6, Allen Herman6 and Wilfred Ngwa1,2,3,4* 1Radiation Oncology, Brigham and Women’s Hospital, Boston, MA, United States 2Dana–Farber Cancer Institute, Boston, MA, United States 3Harvard Medical School, Boston, MA, United States 4University of Massachusetts Lowell, Lowell, MA, United States 5University Medical Center Mannheim, Heidelberg […]