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Canna~Fangled Abstracts

Effects of cannabidiol in males and females in two different rat models of depression.

By December 17, 2018No Comments
2018 Dec 17. pii: S0031-9384(18)30750-9. doi: 10.1016/j.physbeh.2018.12.019.
[Epub ahead of print]
Shbiro L1, Hen-Shoval D2, Hazut N3, Rapps K3, Dar S2, Zalsman G4, Mechoulam R5, Weller A2, Shoval G6.

Abstract

The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.

KEYWORDS:

Animal models of depression; Cannabidiol; Depression; Flinders Sensitive Line; Wistar- Kyoto rats

PMID: 30571957
DOI: 10.1016/j.physbeh.2018.12.019