Skip to main content
Canna~Fangled Abstracts

Serum cannabidiol, tetrahydrocannabinol (THC), and their native acid derivatives after transdermal application of a low-THC Cannabis sativa extract in beagles

By July 31, 2020No Comments
. 2020 Jul 31.

doi: 10.1111/jvp.12896.

Online ahead of print.
Mary Beth Hannon 1, Kelly A Deabold 2, Bryce N Talsma 2, Alex Lyubimov 3, Asif Iqbal 3, Alexander Zakharov 3, Lauri Jo Gamble 1, Joseph J Wakshlag 1
Affiliations

Abstract

Cannabinoids hold promise for treating health problems related to inflammation and chronic pain in dogs, in particular cannabidiol (CBD), and its native acid derivative cannabidiolic acid (CBDA). Information regarding systemic delivery of cannabinoids through transdermal routes is sparse. The purpose of this study was to determine pharmacokinetics of transdermal administration of a low-THC Cannabis sativa extract in healthy dogs. Six purpose-bred research beagles were treated with a transdermal CBD-CBDA-rich extract, and serum concentrations of CBD, CBDA, tetrahydrocannabinol (THC), and its acid derivative tetrahydrocannabinolic acid (THCA) were examined prior to and at the end of weeks 1 and 2. A 4 mg/kg dose of total cannabinoids twice daily resulted in appx 10 ng/ml of CBD, 21-32 ng/ml of CBDA, trace amounts of THCA, and unquantifiable amounts of THC in serum at the end of weeks 1 and 2 of treatment. Results showed that CBDA and THCA were absorbed better systemically than CBD or THC.

 

Keywords: cannabidiol, cannabidiolic acid, dog, hemp, tetrahydrocannabinol, transdermal

References

REFERENCES

    1. Bartner, L. R., McGrath, S., Rao, S., Hyatt, L. K., & Wittenburg, L. A. (2018). Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. Canadian Journal of Veterinary Research, 82, 178-183.
    1. Birnbaum, A. K., Karanam, A., Marino, S. E., Barkley, C. M., Remmel, R. P., Roslawski, M., … Leppik, I. E. (2019). Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy. Epilepsia, 60, 1586-1592. https://doi.org/10.1111/epi.16093
    1. Bråred Christensson, J., Karlberg, A. T., Andersen, K. E., Bruze, M., Johansen, J. D., Garcia-Bravo, B., … White, I. R. (2016). Oxidized limonene and oxidized linalool – concomitant contact allergy to common fragrance terpenes. Contact Dermatitis, 74, 273-280.
    1. Bruni, N., Pepa, C. D., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid delivery systems for pain and inflammation treatment. Molecules, 2478, 1-25. https://doi.org/10.3390/molecules23102478
    1. Eichler, M., Spinedi, L., Unfer-Grauwiler, S., Bodmer, M., Surber, C., Luedi, M., & Drewe, J. (2012). Heat Exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects. Planta Medica, 78, 686-691.

Grant support

Leave a Reply